Impact of alcohol consumption on treatment outcome of hepatocellular carcinoma patients with viral hepatitis who underwent transarterial chemoembolization

Table 3 Univariate and multivariate Cox proportional-hazards model of predictive factors of overall survival after transarterial chemoembolization in individuals with chronic viral hepatitis

Factor	Univariate analysis			Multivariate analysis
	OR	95%CI	P value	HR	95%CI	P value
Female sex	0.722	0.384-1.358	0.312	1.103	0.516-2.359	0.800
Age, every 1-year increase	0.977	0.947-1.008	0.148	1.000	0.968-1.034	0.979
Body mass index < 18.5	0.937	0.439-2.002	0.867
Hepatitis B infection	0.841	0.487-1.453	0.535
Hepatitis C infection	1.270	0.737-2.191	0.389
Alcohol consumption	2.185	1.172-4.074	0.014	2.377	1.109-5.095	0.026
Serum albumin > 3.5 g/dL	0.717	0.414-1.240	0.234
Alpha-fetoprotein > 100 ng/mL	2.174	1.249-3.783	0.006	2.536	1.377-4.670	0.003
Child–Turcotte–Pugh classification			0.115			0.793
A	1	(reference)		1	(reference)
B	1.558	0.898-2.704		1.114	0.498-2.492
MELD score > 10	1.133	0.652-1.968	0.657
Presence of portal hypertension	1.743	0.952-3.191	0.072	2.578	1.320-5.037	0.006
ECOG			0.270
0	1	(reference)
1	1.436	0.755-2.731
Multinodular (> 1 lesion)	1.141	0.512-2.543	0.747
Largest tumor sized > 5 cm	2.203	1.242-3.906	0.007	3.558	1.824-6.939	< 0.001

MELD: Model for End-Stage Liver Disease; ECOG: Eastern Cooperative Oncology Group.