Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection

Table 1 Current diagnostic and tools to assess liver disease stages and severity in hepatitis C virus infected patients

Diagnostic tool	Early fibrosis stages (METAVIR less than F2)	Fibrosis 2	Fibrosis 3	Compensated cirrhosis	Decompensated cirrhosis	Ref.
HCV antibody	Positive	Positive	Positive	Positive	Positive	AASLD and IDSA[30]
Quantitative HCV RNA (viral load)	Positive	Positive	Positive	Positive	Positive
Platelet count < 150000/mm3)	Normal	Normal	Normal	< 150000/mm3	< 150000/mm3
Total and direct bilirubin, ALT & AST	Normal/elevated	Normal/elevated	Normal/elevated	Elevated	Elevated
Child- Pugh	--------	--------	--------	Class A (scores 5-6)	Class B (scores 7-9); Class C (scores 10-15)
FIB-4 Score	< 1.45	≥ 1.45 but < 2.67	≥ 2.67 but < 3.25	≥ 3.25	> 3.25	Filozof et al[31]
Fibroscan by transient elastography	5.3 kPa	7.4 kPa	9.1 kPa	13.2 kPa	13.2 kPa	Platon et al[32]
Fibro test	< 0.48	0.48 - 0.58	> 0.58 but < 0.74	> 0.74	> 0.74	Laboratory Corporation of America[33]
Enhanced liver fibrosis test	< 7.7	7.7	9.8	11.3	11.3	Lichtinghagen et al[34]
Aspartate aminotransferase to platelet ratio index	< 0.77	0.77	0.77	≥ 0.83	≥ 0.83	Lin et al[35]
Liver nodularity and/or splenomegaly	Negative	Negative	Negative	Positive	Positive	AASLD and IDSA[30]
Prior liver biopsy	F0: No fibrosis; F1: Portal fibrosis without septa	F2: Portal Fibrosis with few septa	F3: Numerous septa without cirrhosis	F4: Cirrhosis	F4: Cirrhosis

HCV: Hepatitis C virus.