Copyright
©The Author(s) 2022.
World J Hepatol. Jun 27, 2022; 14(6): 1053-1073
Published online Jun 27, 2022. doi: 10.4254/wjh.v14.i6.1053
Published online Jun 27, 2022. doi: 10.4254/wjh.v14.i6.1053
Diagnostic tool | Early fibrosis stages (METAVIR less than F2) | Fibrosis 2 | Fibrosis 3 | Compensated cirrhosis | Decompensated cirrhosis | Ref. |
HCV antibody | Positive | Positive | Positive | Positive | Positive | AASLD and IDSA[30] |
Quantitative HCV RNA (viral load) | Positive | Positive | Positive | Positive | Positive | |
Platelet count < 150000/mm3) | Normal | Normal | Normal | < 150000/mm3 | < 150000/mm3 | |
Total and direct bilirubin, ALT & AST | Normal/elevated | Normal/elevated | Normal/elevated | Elevated | Elevated | |
Child- Pugh | -------- | -------- | -------- | Class A (scores 5-6) | Class B (scores 7-9); Class C (scores 10-15) | |
FIB-4 Score | < 1.45 | ≥ 1.45 but < 2.67 | ≥ 2.67 but < 3.25 | ≥ 3.25 | > 3.25 | Filozof et al[31] |
Fibroscan by transient elastography | 5.3 kPa | 7.4 kPa | 9.1 kPa | 13.2 kPa | 13.2 kPa | Platon et al[32] |
Fibro test | < 0.48 | 0.48 - 0.58 | > 0.58 but < 0.74 | > 0.74 | > 0.74 | Laboratory Corporation of America[33] |
Enhanced liver fibrosis test | < 7.7 | 7.7 | 9.8 | 11.3 | 11.3 | Lichtinghagen et al[34] |
Aspartate aminotransferase to platelet ratio index | < 0.77 | 0.77 | 0.77 | ≥ 0.83 | ≥ 0.83 | Lin et al[35] |
Liver nodularity and/or splenomegaly | Negative | Negative | Negative | Positive | Positive | AASLD and IDSA[30] |
Prior liver biopsy | F0: No fibrosis; F1: Portal fibrosis without septa | F2: Portal Fibrosis with few septa | F3: Numerous septa without cirrhosis | F4: Cirrhosis | F4: Cirrhosis |
- Citation: Salama II, Raslan HM, Abdel-Latif GA, Salama SI, Sami SM, Shaaban FA, Abdelmohsen AM, Fouad WA. Impact of direct-acting antiviral regimens on hepatic and extrahepatic manifestations of hepatitis C virus infection. World J Hepatol 2022; 14(6): 1053-1073
- URL: https://www.wjgnet.com/1948-5182/full/v14/i6/1053.htm
- DOI: https://dx.doi.org/10.4254/wjh.v14.i6.1053