Functions of three ubiquitin-conjugating enzyme 2 genes in hepatocellular carcinoma diagnosis and prognosis

Figure 7 UBE2C, UBE2T, and UBE2S expression in homo sapiens and protein-protein interaction network. A: Co-expression of UBE2C and UBE2S; B: Co-expression of UBE2C and UBE2T; C: Co-expression of UBE2T and UBE2S; D: Co-expression of UBE2C, UBE2T, and UBE2S predicts functional association. In the triangle matrices above, the intensity of the color indicates the level of confidence that two proteins are functionally associated in Homo sapiens. Figures E-G showed the expression of UBE2C, UBE2T, and UBE2S in HCC based on TP53 mutation status. TCGA samples for analysis; E: UBE2C expression in normal, HCC with TP53 mutation, and HCC non-TP53 mutation samples; F: UBE2T expression in normal, HCC with TP53 mutation, and HCC non-TP53 mutation samples; G: UBE2S expression in normal, HCC with TP53 mutation, and HCC non-TP53 mutation samples. (^cP value < 0.001 Compared with other two groups); H: Protein-protein interaction of functional enrichment of queried network using query input of UBE2C, UBE2T, UBE2S, and TP53.