Effects and safety of natriuretic peptides as treatment of cirrhotic ascites: A systematic review and meta-analysis

Figure 6 Baseline plasma renin activity in selected study subgroups. Non-responders failed to obtain negative sodium balance following intervention with atrial natriuretic peptide (ANP) and were characterised by significantly higher baseline plasma renin activity compared with ANP responders (P < 0.01). Baseline renin activity tended to be lower in subgroups exposed to continuous infusion than for subgroups exposed to bolus injection, while subgroups with refractory ascites had markedly elevated renin activity compared with non-refractory ascites. Dotted line represents overall baseline mean plasma renin activity. ANP: Atrial natriuretic peptide; CI: Confidence interval.