Testosterone therapy reduces hepatic steatosis in men with type 2 diabetes and low serum testosterone concentrations

Table 3 Changes in body composition and metabolic parameters

	Testosterone group (n = 20)	Placebo group (n = 19)	P value
Weight, kg
Baseline	92 (86-101)	98 (91-105)	0.55
40 wk	90 (86-100)	96 (94-100)
BMI, kg/m2
Baseline	30.3 (27.3-31.9)	32.0 (29.7-35.4)	0.64
40 wk	29.3 (27.4-31.8)	31.8 (30.0-34.4)
Waist circumference, cm
Baseline	106 (102-116)	112 (106-118)	0.15
40 wk	108 (101-115)	114 (110-118)
Fasting glucose, mmol/L
Baseline	8.9 (6.8-10.3)	8.6 (7.7-9.8)	0.93
40 wk	8.3 (6.5-10.5)	9.1 (7.7-9.9)
HbA1c, %
Baseline	6.6 (6.4-7.2)	7.0 (6.8-7.4)	0.95
40 wk	7.0 (6.3-7.4)	7.3 (7.0-7.7)
Fat mass, g
Baseline	30788 (24875-38117)	31758 (29332-35286)	< 0.001a
40 wk	27272 (21948-34558)	32089 (29869-34492)
Lean mass, g
Baseline	57090 (51658-62688)	62140 (66226-65844)	< 0.001a
40 wk	58236 (55150-63077)	61070 (57408-64833)
SAT, cm3
Baseline	4445 (2928-5669)	4302 (3828-5254)	0.004a
40 wk	4140 (2769-5046)	4330 (3741-5179)
VAT, cm3
Baseline	3574 (2460-4711)	3864 (3267-4703)	0.63
40 wk	3248 (2280-4634)	3966 (3462-4699)
ALT, U/L
Baseline	34 (26-38)	32 (25-52)	0.27
40 wk	32 (25-36)	44 (29-61)
GGT, U/L
Baseline	30 (21-38)	32 (25-45)	0.28
40 wk	28 (20-41)	33 (28-56)
ALP, U/L
Baseline	72 (60-82)	58 (54-69)	0.04a
40 wk	70 (60-78)	60 (58-72)
Total cholesterol, mmol/L
Baseline	4.4 (4.0-5.0)	4.6 (4.0-4.9)	0.008a
40 wk	3.7 (3.5-4.5)	4.5 (4.1-5.1)
LDL, mmol/L
Baseline	2.4 (2.0-3.0)	2.7 (2.0-3.0)	0.21
40 wk	2.1 (1.8-2.7)	2.4 (1.9-3.2)
HDL, mmol/L
Baseline	(1.01-1.40)	1.02 (0.74-1.18)	0.02a
40 wk	1.19 (0.93-1.36)	0.98 (0.82-1.09)
Triglycerides, mmol/L
Baseline	1.6 (1.3-2.0)	2.0 (1.4-2.4)	0.25
40 wk	1.4 (1.0-1.9)	1.9 (1.6-3.0)

^aP values are an exploratory univariate analysis of between-group week 40 values after adjusting for baseline. No adjustment for multiple comparisons were made given the exploratory nature. Data are median (IQR). BMI: Body mass index; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; GGT: Gamma-glutamyl transferase; TT: Total testosterone; cFT: Calculated free testosterone; SHBG: Sex hormone-binding globulin; LH: Luteinising hormone; LDL: Low-density lipoprotein; HDL: High density lipoprotein; SAT: Subcutaneous adipose tissue; VAT: Visceral adipose tissue.