Noninvasive diagnosis of periportal fibrosis in schistosomiasis mansoni: A comprehensive review

Table 3 Performance of indirect periportal fibrosis markers in Schistosomiasis mansoni infected patients

Marker	Parameters	Performance in S. mansoni infected patients
		Severe PPF			Mild/significant PPF
		Cut-off	Sn (%)	Sp (%)	Cut-off	Sn (%)	Sp (%)
Platelet count[17,26]	Platelet count/mm3	141000[17]	78.5	60	171000[17], 108500[26]	80, 91	91.7, 85
APRI[17,26]	(AST/ULN)/platelet count	1.066	58.5	71.1	0.349[17], 0.440[26]	90, 96	83.3, 85
GGT[17]	GGT/ULN	> 1.55	60.0	75.6	> 0.84	74.6	83.3
Coutinho index[29,30]	(ALP/ULN)/platelet count	≥ 0.330[29], ≥ 0.316[30]	98, 67.4	94.7, 68.3	≥ 0.300, ≥ 0.228	70.8, 68.6	89.5, 46.3

APRI: Aspartate aminotransferase to platelet ratio index; ALP: Alkaline phosphatase; GGT: Gamma glutamyl transferase; PPF: Periportal fibrosis; Sn: Sensitivity; Sp: Specificity; ULN: Upper limit of normality; S. mansoni: Schistosomiasis mansoni.