Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis

Figure 2 Pathological changes in the kidney after treatment. A: Control group; B: Paraffin oil-treated group; C: Fertaric acid (FA)-treated group; D: Bisphenol A (BPA)-treated group; E: FA + BPA-treated rats. It is clear from these figures (H&E staining, 200 ×) that control, paraffin oil-, and FA-treated rats showed a normal size of glomeruli with normal tubules (A-C). BPA-treated rats (D) showed widespread coagulated necrosis with dilatation, vacuolar degeneration, epithelial desquamation, and intraluminal cast formation. FA + BPA-treated rats (E) revealed marked improvement in the histological picture which is comparable to that of the control group.