Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis

Figure 1 Pathological changes in the liver after treatment. A: Control group; B: Paraffin oil-treated group; C: Fertaric acid (FA)-treated group; D: Bisphenol A (BPA)-treated group; E: FA + BPA-treated group. The control, paraffin oil, and FA-treated rats (A, B, and C; H&E staining, 200 ×) showed a normal hepatic architecture with preserved hepatic architecture. On the contrary, in BPA-treated rats (D), there was rim edema in the periportal area (black arrows) which compressed the surrounding hepatocytes. Intra-cytoplasm vacuolation was noted. FA + BPA-treated rats (E) had a preserved hepatic lobular architecture.