Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis

doi:10.4254/wjh.v14.i3.535

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Mar 27, 2022; 14(3): 535-550
Published online Mar 27, 2022. doi: 10.4254/wjh.v14.i3.535

Table 4 Protective effect of fertaric acid on testicular toxicity in rats exposed to bisphenol A

Parameter		Group
Parameter	Control	Paraffin oil	FA	BPA	FA + BPA
Serum Ts (ng/mL)	5.98 ± 0.42	6.00 ± 0.51	5.96 ± 0.62	3.14 ± 0.49^c	5.89 ± 0.68^a
Serum LH (mIU/mL)	18.28 ± 1.85	18.31 ± 1.64	17.96 ± 1.93	33.30 ± 2.21^d	18.15 ± 5.14^b
Serum FSH (mIU/mL)	1.05 ± 0.13	1.03 ± 0.19	0.98 ± 0.15	2.32 ± 0.22^d	1.02 ± 0.18^b
Serum DHEA-SO₄(µg/dL)	197.50 ± 23.29	198.25 ± 26.12	195.74 ± 21.84	154.25 ± 13.56^c	193.72 ± 19.71^a
Serum SHBG (nmol/L)	6.65 ± 0.49	6.67 ± 0.62	6.63 ± 0.51	9.06 ± 1.84^c	6.71 ± 4.95^a
Testis G6PD (U/g tissue)	11.92 ± 0.66	11.94 ± 0.86	11.89 ± 0.73	5.64 ± 0.43^d	10.86 ± 1.52^b
Testis 3βHSD (U/g tissue)	4.46 ± 0.86	4.48 ± 0.75	4.43 ± 0.62	2.15 ± 0.36^d	4.35 ± 0.88^b
Testis Chol (mg/g tissue)	130.67 ± 8.16	132.17 ± 6.90	128.86 ± 7.48	192.53 ± 8.44^d	129.21 ± 7.51^b
Testis protein (mg/g tissue)	290.6 ± 14.23	288.9 ± 16.51	292.19 ± 13.64	187.60 ± 15.18^d	289.45 ± 11.59^b

^aP ≤ 0.05 compared to bisphenol A (BPA).

^bP ≤ 0.01 compared to BPA.

^cP ≤ 0.05 compared to control.

^dP ≤ 0.01 compared to control. Number of animals = 6 rats/group. Values are expressed as the mean ± SD. FA: Fertaric acid; BPA: Bisphenol A; Ts: Testosterone; LH: Luteinizing hormone; FSH: Follicle stimulating hormone; DHEA-SO₄: Dehydroepiandrosterone sulfate; SHBG: Sex hormone binding globulin; G6PD: Glucose-6-phosphate dehydrogenase; 3βHSD: 3β-hydroxysteroid dehydrogenase; Chol: Cholesterol.

Citation: Koriem KMM. Fertaric acid amends bisphenol A-induced toxicity, DNA breakdown, and histopathological changes in the liver, kidney, and testis. World J Hepatol 2022; 14(3): 535-550
URL: https://www.wjgnet.com/1948-5182/full/v14/i3/535.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i3.535