Safety of direct acting antiviral treatment for hepatitis C in oncologic setting: A clinical experience and a literature review

Table 1 Currently used direct aging antiviral characteristics

Trade name	Compound	Year of FDA/EMA approval	Mechanism of action	Pharmaceutical form	Dose	Genotypes
Zepatier	Elbasvir/grazoprevir	2016	NS5A inhibitor/protease inhibitor	Film-coated tablet	50 mg/100 mg qd	1a, 1b, 4
Epclusa	Sofosbuvir/velpatasvir	2016	NS5B inhibitor/ NS5A inhibitor	Film-coated tablet	400 mg/100 mg	Pangenotypic
Maviret	Glecaprevir/pibrentasvir	2017	Protease inhibitor/NS5A inhibitor	Film-coated tablet	100 mg/40 mg qd	Pangenotypic
Vosevi	Sofosbuvir/velpatasvir/voxilaprevir	2018/2017	NS5B inhibitor /NS5A inhibitor/protease inhibitor	Film-coated tablet	400 mg/100 mg/100 mg	Pangenotypic

DAA: Direct aging antiviral; FDA: Food and drug administration; EMA: European Medicines Agency.