Development of the nervous system in mouse liver

Figure 3 Immunohistochemical analysis of the liver at embryonic day 11. 5 by hepatocyte nuclear factor 4α and protein gene product 9.5. A and B: Hepatic progenitors were observed by hepatocyte nuclear factor 4α (HNF4α) immunostaining; B: Liver tissue at a higher magnification than shown in A; C and D: Neurons or neural progenitors were observed by protein gene product 9.5 (PGP9.5) immunostaining; D: Liver tissue at a higher magnification than shown in C. HNF4α was expressed in the nuclei of many cells in the primitive liver; however, PGP9.5 expression was mainly found in the neural tube at the dorsal area of the embryo and but not found in the liver. Scale bar = 200 μm.