Hepatocellular carcinoma in patients with metabolic dysfunction-associated fatty liver disease: Can we stratify at-risk populations?

Table 4 Different risk categories for hepatocellular carcinoma in patients with non-alcoholic fatty liver disease/metabolic-dysfunction associated fatty liver disease¹

Risk for HCC	Patients
Very high	Cirrhosis plus	Male gender
		Older age
		Diabetes
		Low serum albumin
High	Cirrhosis
	F3 fibrosis plus	Elevated AST2
		Low platelets2
		Older age
		Diabetes
Low	F3 fibrosis
Very low	Mild or no liver fibrosis

¹Study of polygenic risk score will be important for better stratification of hepatocellular carcinoma risk when clinically available.

²Probably understaged liver fibrosis.

HCC: Hepatocellular carcinoma.