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World J Hepatol. Feb 27, 2022; 14(2): 354-371
Published online Feb 27, 2022. doi: 10.4254/wjh.v14.i2.354
Table 3 Incidence rate of hepatocellular carcinoma and independent risk factors among patients with non-alcoholic fatty liver disease/metabolic-dysfunction associated fatty liver disease without cirrhosis
Ref.
Population studied
n
Mean follow-up (yr)
Incidence rate of HCC
Independent risk factors
Kanwal et al[28]VHA database (United States)295.6239.0 ± 2.20.08/1000 person-yearsMale gender; Age > 65 yr; hispanics
Lee et al[35]General population-based study (Taiwan of China)18.081Median 6.3210-yr cumulative incidence 2.73% (95%CI: 1.69–3.76)Age > 55 yr; elevated ALT
Alexander et al[36]General population-based study (Europe)136.703Median 3.30.3/1000 person-yearsDiabetes
Kawamura et al[38]Clinic-based study (Japan)6.508Median 5.6Annual incidence 0.043%AST ≥ 40 IU/L; platelet count < 150 × 103/μL; age > 60 yr; diabetes
Arase et al[40]Clinic-based study (Japan)1.6008.20.78/1000 person-yearsAge > 70 yr; smoking; elevated glucose level
Kanwal et al[39]VHA database (United States)271.9069.3 ± 2.7253 cases1Diabetes