Recent updates on progressive familial intrahepatic cholestasis types 1, 2 and 3: Outcome and therapeutic strategies

Figure 1 Bile acid secretion and transport from the hepatocyte across the canalicular membrane and enterohepatic circulation: Role of various transporters involved in transport of bile salts and phospholipids across the canalicular membrane. Enterohepatic circulation of bile salts and their regulation via farnesoid X receptor - fibroblast growth factor 15/19 is also depicted. ABCB: ATP-binding cassette subfamily B; FXR: Farnesoid X receptor; FGF: Fibroblast growth factor; FIC1: Familial intrahepatic cholestasis 1; BSEP: Bile salt exporter pump; MDR3: Multidrug-resistant type 3; BA: Bile acids; NTCP: Sodium taurocholate cotransporting polypeptide; OATs: Organic anion transporters.