Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study

doi:10.4254/wjh.v14.i1.260

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 27, 2022; 14(1): 260-273
Published online Jan 27, 2022. doi: 10.4254/wjh.v14.i1.260

Table 4 The relationship between clinicopathological factors and hepatitis B surface antigen expression patterns with viral response and serological response

	HBeAg positive				HBeAg negative
	VR		SR		VR
Parameters	Absent	Present	Absent	Present	Present
Age (yr)
< Mean	11 (34.4)	39 (72.2)^b	19 (48.7)	31 (66)^b	24 (44.4)
≥ Mean	21 (65.6)	15 (27.8)	20 (51.43)	16 (34)	30 (55.6)
Gender
Male	21 (34.4)	27 (50)	24 (61.5)	24 (48.9)	30 (55.6)
Female	11 (34.4)	27 (50)	15 (38.5)	23 (51.1)	24 (44.4)
HBV DNA
Low	17 (53.1)	39 (72.2)^a	16 (41)	16 (34)	23 (42.6)
High	15 (45.9)	15 (27.8)	23 (59)	31 (66)	31 (57.4)
HBsAg
Low	21 (65.6)	15 (27.8)^a	21 (53.8)	15 (31.9)^b	30 (55.6)
High	11 (34.4)	39 (72.2)	18 (46.2)	32 (68.1)	24 (44.4)
ALT
< 200 IU/L	23 (71.9)	29 (53.7)	29 (74.4)	23 (48.9)^a	39 (72.2)
≥ 200 IU/L	9 (28.1)	25 (46.3)	10 (25.6)	24 (51.1)	15 (27.8)
INR
Low	15 (46.9)	26 (48.1)	19 (48.7)	22 (46.8)	39 (72.2)
High	17 (53.1)	28 (51.9)	20 (51.3)	25 (53.2)	15 (27.8)
Platelets
Low	15 (46.9)	31 (57.4)	20 (51.3)	26 (55.3)	31 (57.4)
High	17 (53.1	23 (42.6)	19 (48.7)	21 (44.7)	23 (42.6)
HAI score ≥ 9	13 (40.6)	25 (46.3)	11 (25)	28 (59.6)^a	23 (42.6)
HAI score < 9	19 (59.4)	29 (53.7)	28 (75)	19 (40.4)	31 (57.4)
Fibrosis ≥ 4	17 (53.1)	16 (29.6)^a	17 (43.6)	16 (34)	20 (37)
Fibrosis < 4	15 (46.9)	10 (70.4)	22 (56.4)	31 (66)	34 (63)
p-HbsAg
Low	26 (81.3)	25 (46.3)^b	29 (74.4)	24 (51.1)^b	21 (38.9)
High	6 (18.8)	29 (53.7)	10 (25.6)	23 (48.9)	33 (61.1)
HBsAg SP1
A	1 (3.1)	16 (29.6)^b	2 (5.1)	15 (31.9)^b	16 (29.6)
B	0	10 (18.5)	0	10 (21.3)	14 (25.9)
C	6 (18.8)	10 (18.5)	11 (28.2)	5 (10.6)	5 (9.3)
D	6 (18.8)	4 (7.4)	6 (15.4)	4 (8.5)	6 (11.1)
E	19 (59.4)	14 (25.9)	20 (51.3)	13 (27.7)	13 (24.1)
HBsAg SP2
Diffuse	1 (3.1)	28 (58.1)^b	2 (5.1)	2 (57.4)^b	30 (55.6)
Globular	12 (37.5)	12 (22.2)	17 (43.6)	7 (14.9)	10 (18.5)
Submembranous	19 (59.4)	14 (25.9)	20 (51.3)	13 (27.7)	14 (25.9)
Membranous expression
Absent	27 (84.4)	26 (48.1)^b	29 (74.4)	24 (51.1)^b	21 (38.9)
Present	5 (15.6)	28 (51.9)	10 (25.6)	23 (48.9)	33 (61.1)

^aP < 0.05.

^bP < 0.01.

VR: Viral response; SR: Serological response; p-HbsAg: Percentage of hepatitis B surface antigen expression; SP: Staining pattern; ALT: Alanine aminotransferase; INR: International normalized ratio; HAI: Histologic activity index; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis B e antigen; HBV: Hepatitis B virus.

Citation: Alpsoy A, Adanir H, Bayramoglu Z, Elpek GO. Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study. World J Hepatol 2022; 14(1): 260-273
URL: https://www.wjgnet.com/1948-5182/full/v14/i1/260.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i1.260