Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study

Table 3 The correlation of clinicopathologic factors and hepatitis B surface antigen expression patterns with viral replication in hepatitis B e antigen negative cases

	HBV DNA		HAI		Fibrosis
Parameters	< 6.65	≥ 6.65	< 9	≥ 9	< 4	≥ 4
n	23	31	31	23	34	20
Age (yr)	48.13 ± 10.34	45.71 ± 12.02	46.52 ± 11.73	47.04 ± 10.92	45.82 ± 11.63	48.30 ± 10.81
Gender
Male	10 (43.5)	20 (64.5)	19 (61.3)	11 (47.8)	23 (67.6)	7 (35)a
Female	13 (56.5)	11 (35.5)	12 (38.7)	12 (52.2)	11 (32.4)	13 (65)
HBV DNA (log10IU/mL)	-	-	4.97 ± 1.49	7.56 ± 1.21a	4.16 ± 0.97	3.98 ± 0.93
HBsAg (log10IU/mL)	3.19 ± 0.84	3.92 ± 0.90	3.30 ± 0.8	3.86 ± 0.91a	3.46 ± 0.95	4.03 ± 0.98
ALT IU/L	96.09 ± 33.55	163.06 ± 50.85a	102.55 ± 41.36	177.65 ± 80.65	126.18 ± 64.87	148.75 ± 58.6
ALT < 200 IU/L	21 (91.3)	18 (58.1)b	26 (83.9)	13 (56.5)a	25 (73.5)	14 (70)
ALT ≥ 200 IU/L	2 (8.7)	13 (41.9)	5 (16.1)	10 (43.5)	9 (26.5)	6 (30)
INR	1.13 ± 0.27	1.17 ± 0.28	1.15 ± 0.3	1.16 ± 0.24	1.22 ± 0.32	1.04 ± 0.10b
Platelets (× 103/μL)	234.91 ± 80.6	216.31 ± 61.29	237.67 ± 73.34	206.64 ± 73.34	218.21 ± 71.85	236.5 ± 68.79
HAI score ≥ 9	2 (8.7)	21 (67.7)b	-	-	14 (26.5)	9 (70)b
HAI score < 9	21 (91.3)	10 (32.3)	-	-	20 (73.5)	11 (30)
Fibrosis ≥ 4	4 (17.4)	16 (51.6)a	6 (19.4)	14 (60.9)b	-	-
Fibrosis < 4	19 (82.6)	15 (48.4)	25 (80.6)	9 (39.1)	-	-
p-HBsAg	30.39 ± 14.18	31.91 ± 14.04	28.68 ± 11.16	34.75 ± 16.71	33.21 ± 15.32	27.96 ± 10.93
HBsAg SP1
A	6 (26.1)	10 (32.3)	13 (41.9)	3 (13)a	13 (38.2)	3 (15)
B	5 (21.7)	9 (29)	5 (16.1)	9 (39.1)	7 (20.6)	7 (35)
C	4 (17.4)	1 (3.2)	4 (12.9)	1 (4.3)	5 (14.7)	0
D	5 (21.7)	1 (3.2)	5 (16.1)	1 (4.3)	3 (8.8)	3 (15)
E	3 (13)	10 (32.3)	4 (12.9)	9 (39.1)	6 (17.6)	7 (35)
HBsAg SP2
Diffuse	11(47.8)	19 (61.3)b	18 (58.1)	12 (52.2)a	20 (58.8)	10 (50)
Globular	9 (39.1)	2 (3.2)	9 (29)	1 (4.3)	7 (20.6)	3 (15)
Submembranous	3 (13.1)	10 (31.5)	4 (12.9)	10 (43.5)	7 (20.6)	7 (35)
Membranous expression
Present	7 (30.4)	13 (41.9)	10 (32.3)	10 (43.5)	14 (41.2)	6 (30)
Absent	16 (69.6)	18 (58.1)	21 (67.7)	13 (56.5)	20 (58.8)	14 (70)

Data are presented as mean ± SD, number (%).

^aP < 0.05.

^bP < 0.01.

p-HbsAg: Percentage of hepatitis B surface antigen expression; SP: Staining pattern; ALT: Alanine aminotransferase; INR: International normalized ratio; HAI: Histologic activity index; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.