Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study

doi:10.4254/wjh.v14.i1.260

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Jan 27, 2022; 14(1): 260-273
Published online Jan 27, 2022. doi: 10.4254/wjh.v14.i1.260

Table 2 The correlation of clinicopathologic factors and hepatitis B surface antigen expression patterns with viral replication in hepatitis B e antigen positive cases

	HBV DNA		HAI		Fibrosis
Parameters	< 7.67	≥ 7.67	< 9	≥ 9	< 4	≥ 4
n	32	54	48	38	53	33
Age (yr)	48.28 ± 9.6	35.57 ± 8.93^b	37.79 ± 10.83	43.47 ± 10.59^a	36.06 ± 9.39	47.12 ± 10.11^b
Gender
Male	23 (71.9)	25 (46.3)^a	23 (47.9)	25 (65.8)	27 (50.9)	21 (63.6)
Female	9 (28.1)	29 (53.7)	25 (52.1)	13 (34.2)	26 (49.1)	12 (36.4)
HBV DNA (log₁₀IU/mL)	-	-	8.36 ± 2.26	6.79 ± 2.30^a	8.15 ± 2.32	6.89 ± 2.34
HBsAg (log₁₀IU/mL)	3.02 ± 0.91	4.59 ± 0.64^b	4.28 ± 0.91	3.66 ± 1.61^a	4.19 ± 1.01	3.07 ± 1.10^a
ALT IU/L	106.97 ± 73.55	184.74 ± 124.85^a	148.97 ± 61.46	121.46 ± 50.84	167.74 ± 72.1	136.64 ± 56.2
ALT< 200 IU/L	26 (81.2)	26 (48.1)^a	34 (70.8)	18 (47.4)^a	32 (60.4)	20 (60.6)
ALT ≥ 200 IU/L	6 (18.8)	28 (51.9)	14 (29.2)	20 (52.6)	21 (39.6)	13 (39.4)
INR	1.03 ± 0.08	1.05 ± 0.16	1.03 ± 0.10	1.06 ± 0.17	1.04 ± 0.16	1.04 ± 0.09
Platelets (× 10³/μL)	217.59 ± 66.85	233.98 ± 80.60	226 ± 74.74	228 ± 77.51	224.53 ± 74.72	232.61 ± 77.82
HAI score ≥ 9	22 (68.8)	16 (29.6)^b	-	-	17 (32.1)	21 (63.6)^b
HAI score < 9	10 (31.2)	38 (70.4)	-	-	36 (67.9)	12 (36.4)
Fibrosis ≥ 4	19 (59.4)	14 (25.9)^a	12 (25)	21 (55.3)^b	-	-
Fibrosis < 4	13 (40.6)	40 (74.1)	36 (75)	17 (44.7)	-	-
p-HBsAg	29.92 ± 10.84	57.44 ± 25.50^b	53.53 ± 25.12	39.21 ± 22.85^a	54.49 ± 26.02	35.49 ± 18.34^b
HBsAg SP1
A	2 (6.2)	15 (27.8)^a	11 (22.9	6 (15.8)^a	17 (32.1)	0^b
B	4 (12.5)	6 (11.1)	1 (2.1)	9 (23.7)	6 (11.3)	4 (12.1)
C	6 (18.8)	10 (18.5)	12 (25)	4 (10.5)	14 (26.4)	2 (6.1)
D	4 (12.5)	6 (11.1)	7 (14.6)	3 (7.9)	8 (15.1)	2 (6.1)
E	16 (50)	17 (31.5)	17 (35.4)	16 (42.1)	8 (15.1)	25 (75.8)
HBsAg SP2
Diffuse	8 (25)	21 (38.9)	12 (25)	17 (44.7)^a	23 (43.4)	6 (18.2)^b
Globular	8 (25)	16 (29.6)	19 (39.6)	5 (13.1)	22 (41.5)	2 (6.1)
Submembranous	16 (50)	17 (31.5)	17 (35.4)	16 (42.1)	8 (15.1)	25 (75.8)
Membranous expression
Present	5 (15.6)	28 (51.9)^b	21 (43.8)	12 (31.6)	29 (54.7)	4 (12.1)^b
Absent	27 (84.4)	26 (48.1)	27 (56.3)	26 (68.4)	24 (45.3)	29 (87.9)

Data are presented as mean ± SD, number (%).

^aP < 0.05.

^bP < 0.01.

p-HbsAg: Percentage of hepatitis B surface antigen expression; SP: Staining pattern; ALT: Alanine aminotransferase; INR: International normalized ratio; HAI: Histologic activity index; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.

Citation: Alpsoy A, Adanir H, Bayramoglu Z, Elpek GO. Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study. World J Hepatol 2022; 14(1): 260-273
URL: https://www.wjgnet.com/1948-5182/full/v14/i1/260.htm
DOI: https://dx.doi.org/10.4254/wjh.v14.i1.260