Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study

Table 1 Basic clinical, histopathological and immunohistochemical findings according to hepatitis B e antigen status

Parameters	Total	HBeAg positive	HBeAg negative
n	140	86	54
Age (yr)	42.75 ± 11.53	40.30 ± 11.03	46.74 ± 11.29a
Gender
Male	78	48 (61.5)	30 (38.5)
Female	62	38 (61.3)	24 (38.7)
HBV DNA (log10IU/mL)	7.27 ± 2.17	7.67 ± 2.39	6.65 ± 1.58a
HBsAg (log10IU/mL)	3.85 ± 1.04	4.01 ± 1.07	3.61 ± 0.94b
ALT IU/L	7.27 ± 2.17	155.80 ± 114.32	134.54 ± 98.71
ALT < 200 IU/L	91	52 (51.7)	39 (42.9)
ALT ≥ 200 IU/L	49	34 (69.4)	15 (30.6)
INR	1.08 ± 0.21	1.04 ± 0.14	1.15 ± 0.27b
Platelets (× 103/μL)	226.4 ± 73.43	224.54 ± 70.67	227.59 ± 75.53
HAI score ≥ 9	61	38 (62.3)	23 (37.7)
HAI score < 9	79	48 (60.8)	31 (39.2)
Fibrosis ≥ 4	53	33 (62.3)	20 (37.7)
Fibrosis < 4	87	53 (60.9)	34 (39.1)
p-HBsAg	41.05 ± 22.78	47.2 ± 13.98	31.26 ± 13.98a
HBsAg SP1
A	33	17 (51.5)	16 (48.5)
B	24	10 (41.7)	14 (58.3)
C	21	16 (76.2)	5 (23.8)
D	16	10 (62.5)	6 (37.5)
E	46	33 (71.7)	13 (28.3)
HBsAg SP2
Diffuse	59	29 (49.2)	30 (50.8)
Globular	34	24 (70.6)	10 (29.4)
Submembranous	47	33 (70.2)	14 (29.8)
Membranous expression
Present	53	33 (63.3)	20 (37.7)
Absent	87	53 (60.9)	34 (39.1)

Data are presented as mean ± SD, number (%).

^aP < 0.05.

^bP < 0.01.

p-HbsAg: Percentage of hepatitis B surface antigen expression; SP: Staining pattern; ALT: Alanine aminotransferase; INR: International normalized ratio, HAI: Histologic activity index; HBsAg: Hepatitis B surface antigen; HBV: Hepatitis B virus.