Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

Table 3 Comparison between changes in inflammatory and liver functional markers before and after laparoscopic and open liver resection

Factors	LLR	OLR	P
	n = 10	n = 20
Total bilirubin, mg/dL
Preoperatively	0.8 (0.4-1.4)	0.8 (0.4-2.6)	0.69
POD5	0.7 (0.5-0.9)	0.9 (0.3-5.2)	0.11
POD30	0.7 (0.3-1.1)	0.7 (0.4-2.5)	0.95
Bile acid, μmol/L
Preoperatively	7.4 (0.8-16.8)	12.4 (0.7-82.1)	0.21
POD3	4.9 (0.6-20.8)	9.9 (1.6-56.7)	0.13
Albumin, g/dL
Preoperatively	3.8 (3.5-4.5)	3.6 (2.9-4.4)	0.08
POD5	3.0 (2.4-3.3)	3.0 (2.3-3.5)	0.77
POD30	3.9 (3.4-4.6)	3.6 (2.2-4.4)	0.16
Neutrophil, %
Preoperatively	62.1 (46.7-74.3)	67.3 (28.8-85.2)	0.17
POD1	82.5 (68.1-92.7)	83.1 (70.7 – 92.2)	0.86
POD3	70.9 (58.7-83.7)	76.3 (52.9-86.6)	0.20
POD5	69.2 (46.3-80.4)	67.6 (45.1-80.9)	0.95
POD7	67.3 (49.8-76.7)	69.3 (38.3-77.5)	0.42
CRP, mg/dL
Preoperatively	0.07 (0.01-2.67)	0.07 (0.01-3.50)	0.57
POD1	0.96 (0.24-6.32)	1.48 (0.38-4.94)	0.28
POD3	2.04 (0.62-9.16)	5.93 (1.12-16.48)	0.01
POD5	1.18 (0.20-5.83)	4.36 (0.44-14.3)	0.01
POD7	0.65 (0.11-1.52)	2.77 (0.31-9.97)	0.01

LLR: Laparoscopic liver resection; OLR: Open liver resection; POD: Postoperative days; CRP: C-reactive protein.