Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

Table 2 Time course of circulating serum level of interleukin-6 and plasma level of thrombospondin-1 before and after laparoscopic and open liver resection

Factors	LLR	OLR	P
	n = 10	n = 20
IL-6, pg/mL
Preoperatively	3.9 (2.6-43.6)	3.7 (2.0-68.8)	0.50
Postoperatively	30.8 (4.9-189.8)	73.6 (4.7-348.8)	0.14
POD1	8.7 (4.8-359.3)	30.3 (10.8-376.3)	0.003
POD3	9.3 (4.1-99.7)	31.7 (7.0-212.3)	0.03
TSP-1, ng/mL
Preoperatively	1817.1 (141.7-2985.7)	2025.1 (124.6-3815.0)	0.98
Postoperatively	1364.7 (84.1-2459.3)	684.4 (42.5-3580.3)	0.52
POD1	589.1 (139.3-3186.4)	233.6 (36.6-4058.3)	0.12
POD3	1704.0 (665.4-3399.2)	548.3 (30.4-2239.2)	0.009

TSP-1: Thrombospondin-1; IL-6: Interleukin-6; LLR: Laparoscopic liver resection; OLR: Open liver resection; POD: Postoperative days.