Assessment for the minimal invasiveness of laparoscopic liver resection by interleukin-6 and thrombospondin-1

Table 1 Clinical characteristics of study patients

Factors	LLR	OLR	P
	n = 10	n = 20
Age, years	74 (31-94)	71 (35-83)	0.91
Sex (male/female)	6/4	12/8	1.0
HBs-Ag (positive/negative)	0/10	2/18	0.20
HCV-Ab (positive/negative)	4/6	8/12	1.0
White blood cell, × 103 /uL	5.5 (3.1-6.0)	6.8 (2.5-10.6)	0.23
Platelet, × 104 /uL	16.4 (11.2-21.2)	17.5 (8.3-88.0)	0.36
Prothrombin time, %	102 (69-122)	105 (65-126)	0.86
AST, U/L	23 (14-48)	27 (13-175)	0.52
ALT, U/L	23 (10-46)	26 (6-103)	0.31
ALP, U/L	221 (138-375)	243 (134-676)	0.36
ChE, U/L	263 (154-327)	231 (121-357)	0.39
ICG R15, %	10.4 (4.5-24.7)	10.6 (0.9-65.4)	0.84
Child-Pugh classification (A/B)	10/0	18/2	0.20
Difficulty scoring system	4 (2-5)	4 (2-6)	0.44
Operative time, min	290 (126-660)	385 (82-633)	0.88
Bleeding volume, mL	57 (5-750)	528 (116-9527)	0.003
Resected liver volume, g	66.5 (4-206)	77.5 (2-220)	0.76
Longest diameter of the tumor, mm	17 (6-53)	25 (7-55)	0.27
Number of resected lesion	1 (1-2)	2 (1-7)	0.1
Surgical margin, mm	5 (0-55)	1 (0-22)	0.24
Diagnosis(primary/metastasis/benign)	7/2/1	13/6/1	0.77
Postoperative hospital stay, d	10 (6-14)	14 (8-26)	0.003
Complications (no/yes)	10/0	17/3	0.1

No complication means less than IIIa at clavien-dindo classification. LLR: Laparoscopic liver resection; OLR: Open liver resection; HBs-Ag: hepatitis B surface antigen; HCV-Ab: hepatitis C antibody; AST: Aspartate aminotransferase; ALT: Alanine aminotransferase; ALP: Alkaline phosphatase; ChE: Cholinesterase; ICG-R15: Retention of indocyanine green at 15 min.