Global prevalence of hepatitis B virus serological markers among healthcare workers: A systematic review and meta-analysis

doi:10.4254/wjh.v13.i9.1190

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World Journal of Hepatology

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Meta-Analysis

World J Hepatol. Sep 27, 2021; 13(9): 1190-1202
Published online Sep 27, 2021. doi: 10.4254/wjh.v13.i9.1190

Table 1 Summary of meta-analysis results for global seroprevalence of hepatitis B virus serological markers in healthcare workers

	Prevalence % (95%CI)	95% Prediction interval	Studies, n	Participants, n	¹H (95%CI)	²I² (95%CI)	P value (heterogeneity)	P value (Egger test)
Current HBV infection (HBsAg)
Overall	2.4 (2-2.8)	0-11	275	153326	4.1 (4-4.3)	94.1 (93.6-94.5)	< 0.001	< 0.001
Cross-sectional	2.4 (2-2.9)	0-11.1	271	150516	4.1 (4-4.3)	94.2 (93.7-94.6)	< 0.001	< 0.001
Low risk of bias	1.8 (1.4-2.3)	0-8.2	107	40212	3 (2.8-3.2)	88.8 (87-90.3)	< 0.001	< 0.001
Current HBV infection (HBeAg)
Overall	0.3 (0-1.7)	0-70.6	3	4408	3.6 (2.3-5.7)	92.3 (80.7-96.9)	< 0.001	0.577
Cross-sectional	0.3 (0-1.7)	0-70.6	3	4408	3.6 (2.3-5.7)	92.3 (80.7-96.9)	< 0.001	0.577
Low risk of bias	0 (0-0.1)	NA-NA	1	3513	NA (NA-NA)	NA (NA-NA)	1	NA
HBV acute infection
Overall	5.4 (1.4-11.3)	0-37	12	3665	6.1 (5.3-7.1)	97.3 (96.4-98)	< 0.001	0.256
Cross-sectional	5.4 (1.4-11.3)	0-37	12	3665	6.1 (5.3-7.1)	97.3 (96.4-98)	< 0.001	0.256
Low risk of bias	1.9 (0-8.7)	0-48.1	5	1639	6.5 (5.1-8.2)	97.6 (96.2-98.5)	< 0.001	0.824
Immunity against HBV
Overall	56.6 (49.3-63.7)	2.8-100	84	37622	14 (13.5-14.4)	99.5 (99.5-99.5)	< 0.001	0.763
Cross-sectional	56.3 (48.8-63.7)	2.4-100	80	36311	14.2 (13.8-14.7)	99.5 (99.5-99.5)	< 0.001	0.811
Low risk of bias	65.9 (56.1-75.1)	10.3-100	35	22401	14.7 (14.1-15.4)	99.5 (99.5-99.6)	< 0.001	0.974
Immunity due to natural HBV infection
Overall	9.2 (6.9-11.8)	0-34.5	57	23002	6.3 (5.9-6.7)	97.4 (97.1-97.8)	< 0.001	0.853
Cross-sectional	9.2 (6.9-11.9)	0-34.6	56	22867	6.3 (5.9-6.7)	97.5 (97.1-97.8)	< 0.001	0.851
Low risk of bias	7 (4-10.8)	0-30.3	20	10408	6.4 (5.7-7.1)	97.6 (97-98)	< 0.001	0.463

¹H is a measure of the extent of heterogeneity, a value of H =1 indicates homogeneity of effects and a value of H > 1 indicates a potential heterogeneity of effects.

²I² describes the proportion of total variation in study estimates that is due to heterogeneity, a value > 50% indicates presence of heterogeneity.

HBV: Hepatitis B virus; HBsAg: Hepatitis B surface antigen; HBeAg: Hepatitis e antigen; CI: Confidence interval; NA: Not available.

Citation: Mahamat G, Kenmoe S, Akazong EW, Ebogo-Belobo JT, Mbaga DS, Bowo-Ngandji A, Foe-Essomba JR, Amougou-Atsama M, Monamele CG, Mbongue Mikangue CA, Kame-Ngasse GI, Magoudjou-Pekam JN, Zemnou-Tepap C, Meta-Djomsi D, Maïdadi-Foudi M, Touangnou-Chamda SA, Daha-Tchoffo AG, Selly-Ngaloumo AA, Nayang-Mundo RA, Yéngué JF, Taya-Fokou JB, Fokou LKM, Kenfack-Momo R, Tchami Ngongang D, Atembeh Noura E, Tazokong HR, Demeni Emoh CP, Kengne-Ndé C, Bigna JJ, Boyomo O, Njouom R. Global prevalence of hepatitis B virus serological markers among healthcare workers: A systematic review and meta-analysis. World J Hepatol 2021; 13(9): 1190-1202
URL: https://www.wjgnet.com/1948-5182/full/v13/i9/1190.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i9.1190