Non-invasive tests for predicting liver outcomes in chronic hepatitis C patients: A systematic review and meta-analysis

Table 2 Pooled unadjusted and adjusted hazard ratios of pre- and post-treatment fibrosis-4 index, aspartate aminotransferase to platelet ratio index, liver stiffness measurement for the prediction of hepatocellular carcinoma development

Analysis	HR				aHR
	Pooled HR (95%CI)	I2 (%)	Ref.	No. of cases	Pooled aHR (95%CI)	I2 (%)	Ref.	No. of cases
FIB-4	5.17 (4.03-6.63)	76	[13,29,30,38,40-42]	1831	2.48 (1.91-3.23)	96	[13,33,39-42,44,49]	1842
pre-Rx	4.91 (3.71-6.49)	81	[13,38,40-42]	1781	3.20 (1.77-5.80)	97	[13,33,39-40,42,44]	1699
post-Rx with SVR	5.44 (2.25-13.15)	69	[29,30,38,41]	173	3.01 (0.32-28.61)	89	[33,49]	21
APRI	5.27 (2.34-11.83)	91	[31,40,41]	150	4.24 (2.15-8.38)	20	[33,36,41]	149
pre-Rx	4.23 (1.42-12.62)	83	[31,40,41]	142	-	-	[33]	12
post-Rx with SVR	9.33 (5.85-14.88)	0	[31,41]	130	9.88 (2.21-44.16)	24	[33,41]	134
LSM	9.45 (4.49-19.92)	70	[14,15,29,30,34,38]	301	7.90 (3.98-15.68)	52	[15,29,30,32,34,35,38]	362
pre-Rx	4.68 (2.00-10.96)	40	[15,38]	54	3.76 (1.77-8.02)	7	[15,35,38]	63
post-Rx with SVR	8.90 (4.10-19.33)	36	[14,29,30,38]	76	6.33 (2.57-15.59)	17	[29,30,38]	51

aHR: Adjusted hazard ratio; APRI: Aspartate aminotransferase to platelet ratio index; FIB-4: Fbrosis-4 index; HCC: Hepatocellular carcinoma; LSM: Liver stiffness measurement; pre-Rx: Pre-treatment; post-Rx with SVR: Post-treatment with sustained virologic response.