Non-invasive tests for predicting liver outcomes in chronic hepatitis C patients: A systematic review and meta-analysis

Table 1 Characteristics of the cohort studies included in the systematic review

Ref.	Country	n	NITs	Outcomes
Chun et al[49], 2020	South Korea	669	FIB-4	HCC
Chalouni et al[18], 2019	France	998	APRI, FIB-4, TE	LRE
Chen et al[45], 2019	China	691	FIB-4	OM
Hansen et al[20], 2019	Denmark	591	TE	OM, LRD, HD
Ioannou et al[13], 2019	United States	48135	FIB-4	HCC
Na et al[33], 2019	South Korea	295	APRI, FIB-4	HCC
Nakagomi et al[34], 2019	Japan	1146	TE	HCC
Ogasawara et al[38], 2019	Japan	398	FIB-4, TE	HCC, HD
Ogasawara et al[47], 2019	Japan	457	FIB-4	OM
Peleg et al[23], 2019	Israel	515	TE	HCC, OM, HD
Pons et al[14], 2019	Spain	572	TE	HCC
Rinaldi et al[15], 2019	Italy	258	TE	HCC
Shili-Masmoudi et al[28], 2019	France	1062	TE	OM, LRM
Sou et al[41], 2019	China	1884	APRI, FIB-4	HCC
Tamaki et al[30], 2019	Japan	346	FIB-4, MRE	HCC
Watanabe et al[44], 2019	Japan	1174	APRI, FIB-4	HCC
Bloom et al[17], 2018	Australia	780	TE	LRE
Hamada et al[29], 2018	Japan	196	FIB-4, SWE	HCC
Munteanu et al[22], 2018	France	3449	Fibrotest	OM, LRM
Cepeda et al[25], 2017	United States	964	TE	OM
Gomez-Moreno et al[19], 2017	Spain	343	TE	HCC, HD, LRM
Merchante et al[26], 2017	Spain	446	TE	HD
Thandassery et al[43], 2017	Qatar	1605	APRI, FIB-4	HCC, HD, LRE
Akuta et al[39], 2016	Japan	958	FIB-4	HCC
Lee et al[31], 2016	South Korea	598	APRI	HCC
Lee et al[46], 2016	South Korea	190	TE	LRE
Ng et al[36], 2016	China	105	APRI	HCC
Pérez-Latorre et al[24], 2016	Spain	957	TE	LRE, OM
Sato et al[40], 2016	Japan	355	APRI, FIB-4	HCC
Tada et al[48], 2016	Japan	1723	FIB-4	LRM, OM
Berenguer et al[12], 2015	Spain	903	FIB-4	LRE, OM
Macías et al[21], 2015	Spain	1046	TE	HD, OM
Narita et al[35], 2014	Japan	151	TE	HCC
Nojiri et al[37], 2014	Japan	142	APRI, FIB-4, Forns index	HCC
Tamaki et al[42], 2014	Japan	1046	FIB-4	HCC
Bambha et al[16], 2012	United States	450	APRI, FIB-4	OM
Nunes et al[27], 2010	United States	303	APRI, FIB-4	LRM
Masuzaki et al[32], 2009	Japan	984	TE	HCC
Yu et al[11], 2006	China	1338	APRI	HCC, OM

N/A: Not available; APRI: Aspartate aminotransferase to platelet ratio index; FIB-4: Fibrosis-4 index; HCC: Hepatocellular carcinoma; HD: Hepatic decompensation; LSM: Liver stiffness measurement; LRM: Liver-related mortality; LRE: Liver-related event; NIT: Non-invasive test; OM: Overall mortality; TE: Transient elastography; MRE: Magnetic resonance elastography.