Role of chromosome 1q copy number variation in hepatocellular carcinoma

Table 1 Amplified genes within/near 1q21-23 that have been associated with hepatocellular carcinoma

Gene1	Location2	Description of protein product	Ref.
JTB	1q21.3	Promotes cell resistance to apoptosis	Wong et al[11] and Kanome et al[12]
SHC1	1q21.3	Downstream signaling from receptor tyrosine kinases	Wong et al[11], Midorikawa et al[8], Pelicci et al[13], Kavanaugh and Williams[14], and van der Geer et al[15]
CCT3	1q22	Associated with cell cycle regulation	Wong et al[11], Midorikawa et al[8], Won et al[16]
COPA	1q23.2	Assists in retrograde vesicular transport from Golgi to endoplasmic reticulum	Wong et al[11] and Vece et al[17]
CKS1B	1q21.2	Associated with cell cycle regulation	Midorikawa et al[8] and Ganoth et al[19]
HAX-1 (HAX1)	1q21.3	Plays a role in the activation of receptor tyrosine kinases	Midorikawa et al[8] and Suzuki et al[18]
CREB3L4	1q21.3	Associated with androgen receptor signaling	Inagaki et al[21] and Qi et al[22]
INTS3	1q21.3	Associated with RNA polymerase II	Inagaki et al[21] and Baillat et al[24]
SNAPAP (SNAPIN)	1q21.3	Part of SNARE complex (docking and fusion of synaptic vesicles)	Inagaki et al[21] and Ilardi et al[25]
ALC1 (CHD1L)	1q21.1	Facilitates DNA synthesis and cell cycle when over expressed	Ma et al[26]
ASH1L	1q22	Histone methyltransferase involved in gene expression	Elsemman et al[27] and An et al[29]
METTL13 (EEF1AKNMT)	1q24.3	Regulates protein synthesis in cancer cells; promotes tumor growth and metastasis	Elsemman et al[27]; Liu et al[30], and Li et al[31]
TARBP1	1q42.2	Double-stranded RNA binding protein; promotes HIV-1 and -2 and HCV replication	Elsemman et al[27], Zhang et al[50], and Christensen et al[32]
SMYD2	1q32.2	Part of the protein lysine methyltransferase family of enzymes	Elsemman et al[27] and Leinhart and Brown[34]
SMYD3	1q44	Part of the protein lysine methyltransferase family of enzymes	Elsemman et al[27] and Leinhart and Brown[34]

¹Alternative gene designation provided in parentheses (see text).

²Chromosome locations are as found on the Genome Browser at http://genome.ucsc.edu[65]. HIV: Human immunodeficiency virus; HCV: Hepatitis C virus.