Combination of type IV collagen 7S, albumin concentrations, and platelet count predicts prognosis of non-alcoholic fatty liver disease

Table 1 Clinical and histological characteristics of the patient population (n = 489)

Characteristics	Values
Age	50.1 (14-82)
Male sex, %	54.6
Body mass index, kg/m2	26.9 (20.8-49.5)
Fibrosis stage, 0/1/2/3/4	65/173/111/122/18
Grade, 0/1/2/3	45/204/178/62
Steatosis, 0/1/2/3	13/158/228/90
NAFLD activity score, < 4/≥ 5	265/224
ALT, IU/L	69 (2-563)
AST, IU/L	43 (13-312)
γ-GTP, IU/L	60 (12-736)
Total bilirubin, mg/dL	0.8 (0.04-2.7)
Total cholesterol, ng/dL	198 (102-317)
Cholinesterase, IU/L	205 (90-337)
Platelet count, × 104/μL	20.8 (6.6-44.7)
Albumin, g/dL	4.5 (2.5-5.4)
HOMA-IR	2.9 (0.7-22.4)
Iron, μg/dL	119 (13-295)
Ferritin, ng/dL	149 (3.9-983)
Leptin, ng/dL	9.3 (1.1-59.3)
Adiponectin, μg/mL	5.5 (2.0-27.5)
High-sensitivity CRP, mg/dL	0.117 (0.01-1.92)
P-III-P, U/mL	0.7 (0.28-3.8)
Type IV collagen 7S, ng/mL	4.1 (1.9-15)
Hyaluronic acid, ng/mL	28 (9-619)
Fibrosis-4 index	1.29 (0.17-1.29)

NAFLD: Non-alcoholic fatty liver disease; ALT: Alanine aminotransferase; AST: Aspartate aminotransferase; γ-GTP: Gamma-glutamyl transpeptidase; HOMA-IR: Homeostatic model assessment of insulin resistance; CRP: C-reactive protein; P-III-P: Procollagen-III peptide.