Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study

Figure 5 Effect of diethylnitrosamine and 2-acetylaminofluorene at different doses. A: Relative quantification (RQ) of RAB11A mRNA; B: RQ of BAX mRNA; C: RQ of p53 mRNA; D: RQ of Cyclin E mRNA in the liver and serum in rats. Values are mean ± SE; number of animals = 6 rats/each group. ^aP < 0.05 compared to the naïve group; ^bP < 0.05 compared to the diethylnitrosamine (DEN) group at week 10 group; ^cP < 0.05 compared to the DEN at week 16 group; ^dP < 0.05 when DEN 200 + acetylaminofluorene (AAF) is compared to the DEN 100 + AAF; ^eP < 0.05 when DEN 300 + AAF is compared to the DEN 100 + AAF; ^fP < 0.05 when DEN 300 + AAF is compared to the DEN 200 + AAF. One-way ANOVA followed by Tukey's multiple comparison test. DEN: Diethylnitrosamine; 2-AAF: 2-Acetylaminofluorene.