Molecular pathways of liver regeneration: A comprehensive review

Figure 1 Typical liver regeneration. A: Priming phase. Mature hepatocytes undergo the G0-G1 transition driven by interleukin-6 and tumor necrosis factor-α. Sinusoid endothelial cells produce urokinase plasminogen activator in response to increased blood pressure. Urokinase plasminogen activator activates matrix metalloproteinase, resulting in extracellular matrix remodeling and the release of growth factors; B: Proliferative phase. Numerous factors, including Wnt-ligands, growth factors and bile acids, lead to the transcription of cyclin-dependent kinase and cyclins, resulting in the S-M transition and hepatocyte proliferation. Bile acids also suppress the synthesis of inflammatory cytokines by Kupffer cells; C: Termination phase. Different factors, primarily tumor necrosis factor-β family members, initiate the cell cycle arrest of hepatocytes and reversion to the G0 phase and cause the apoptosis of newly formed cells to correct the excessive regenerative response. TNF-α: Tumor necrosis factor-α; IL-6: Interleukin-6; MMP: Matrix metalloproteinase; KC: Kupffer cells; SEC: Sinusoid endothelial cells; HGF: Hepatocyte growth factor; EGFR: Epidermal growth factor receptor; MAPK: Mitogen-activated protein kinase.