Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation

Table 1 Characteristics of the included studies

Ref.	Year	Country	Study design	Follow-up period	Sample size	Donor type	Mean age	Concurrent therapy
Alloway et al[11]	2014	United States	Phase-II, 3-sequence, open-label, multicenter, prospective study	1 yr	59	NR	49.8	Mycophenolate mofetil
Kim et al[13]	2016	South Korea	2-armed, parallel group, prospective, randomized, open-label, phase IV	1 yr	79	Deceased	54	NR
Sańko-Resmer et al[14]	2012	United Kingdom	Multicentre, open-label, single-sequence, crossover, phase IIIb	3 mo	98	NR	55	None
Shin et al[17]	2018	South Korea	Phase IV, randomized, open-label, comparative, single-center study	6 mo	100	NR	52	Corticosteroid, mycophenolate mofetil, and basiliximab.
Trunečka et al[15]	2010	16 countries	1:1-randomized, double-blind, double-dummy, two-arm, parallel-group phase III, comparative study	1 yr	471	NR	52	Mycophenolate sodium
DuBay et al[12]	2019	United States	Phase II, open label, multicenter, randomized trial	1 yr	29	Deceased	54.4	Mycophenolate mofetil, mycophenolic acid sodium, prednisone, or azathioprine
Fischer et al[16]	2010	Germany	Randomized, phase II, multicenter, open-label, prospective trial	6 wk	129	NR	47	Anti-fungal, antibiotics, anti-hypertensives, antiepileptics and rifampicin)

NR: Not reported.