Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study

doi:10.4254/wjh.v13.i3.328

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Mar 27, 2021; 13(3): 328-342
Published online Mar 27, 2021. doi: 10.4254/wjh.v13.i3.328

Table 3 Effect of diethylnitrosamine and 2-acetylaminofluorene on relative quantification of lncRNA-RP11-513I15.6 (long-noncoding RNA), relative quantification of miR-1262 and relative quantification of miR-1298 (microRNA)

	RQ of lncRNA-RP11-513I15.6		RQ of miR-1262		RQ of miR-1298
	Liver	Serum	Liver	Serum	Liver	Serum
Naïve	2.33 ± 0.31	1.86 ± 0.41	0.38 ± 0.09	0.26 ± 0.34	0.77 ± 0.26	0.1 ± 0.04
Week 10
DEN	1.31 ± 0.36^d	0.99 ± 0.15^d	1.63 ± 0.28^d	1.40 ± 0.13^d	1.55 ± 0.37^d	1.08 ± 0.11^d
DEN + 100 AAF	1.03 ± 0.2^d	0.63 ± 0.13^d^,^e	2.26 ± 0.54^d	2.23 ± 0.19^d	1.85 ± 0.12^d	1.48 ± 0.56^d
DEN + 200 AAF	0.58 ± 0.12^a^,^d^,^e	0.44 ± 0.05^d^,^e	2.52 ± 0.44^d^,^e	2.81 ± 0.49^d^,^e	2.46 ± 0.37^d^,^e	1.82 ± 0.47^b^,^c^,^d^,^e
DEN + 300 AAF	0.47 ± 0.037^b^,^d^,^e	0.39 ± 0.005^d^,^e	3.9 ± 0.36^d^,^e	3.59 ± 1.10^b^,^d^,^e	2.88 ± 0.11^d^,^e	3.30 ± 0.18^d^,^e
Week 16
DEN	0.76 ± 0.1^d	0.52 ± 0.13^d	3.12 ± 0.62^d	2.15 ± 0.08^d	2.52 ± 0.56^d	2.23 ± 0.26^d
DEN + 100 AAF	0.46 ± 0.04^d^,^f	0.22 ± 0.04^d	4.48 ± 0.63^d^,^f	4.08 ± 0.32^d	3.92 ± 0.61^d^,^f	4.56 ± 0.61^d^,^f
DEN + 200 AAF	0.26 ± 0.07^d^,^f	0.14 ± 0.07^d^,^f	5.71 ± 0.76^a^,^d^,^f	7.38 ± 2.24^d^,^f	4.58 ± 0.56^d^,^f	5.78 ± 1.72^d^,^f
DEN + 300 AAF	0.14 ± 0.04^b^,^d^,^f	0.12 ± 0.06^d^,^f	6.45 ± 1.04^b^,^d^,^f	9.78 ± 4.32^b^,^d^,^f	5.89 ± 1.27^d^,^f	7.38 ± 2.05^b^,^d^,^f

Values are mean ± SD; number of animals = 6 rats/each group.

^aP < 0.05 when DEN + 200 acetylaminofluorene (AAF) is compared to the DEN + 100 AAF.

^bP < 0.05 when DEN + 300 AAF is compared to the DEN + 100 AAF.

^cP < 0.05 when DEN + 300 AAF is compared to the DEN + 200 AAF.

^dP < 0.05 compared to the naïve group.

^eP < 0.05 compared to the diethylnitrosamine (DEN) group at week 10 group.

^fP < 0.05 compared to the DEN at week 16 group. One-way ANOVA followed by Tukey's multiple comparison test. DEN: Diethylnitrosamine; 2-AAF: 2-Acetylaminofluorene; RQ: Relative quantification; lncRNA: Long-noncoding RNA; miR: MicroRNA.

Citation: Hasanin AH, Habib EK, El Gayar N, Matboli M. Promotive action of 2-acetylaminofluorene on hepatic precancerous lesions initiated by diethylnitrosamine in rats: Molecular study. World J Hepatol 2021; 13(3): 328-342
URL: https://www.wjgnet.com/1948-5182/full/v13/i3/328.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i3.328