Molecular pathways of liver regeneration: A comprehensive review

Table 2 Main micro ribonucleic acids influencing liver regeneration

miRNA	Expression change	Target genes	Influence on LR
miR-21	Increased	Rhob, Sox7, Crebl2, Bcl-2, Btg2, Timp3, Reck, Pdcd4, Tgfbi, Smad7, PTEN	Induction
miR -19a	Increased	PTEN	Induction
miR-214	Increased	PTEN	Induction
miR-203	Increased	SOCS3	Induction
miR-27a/b	Increased	Tmub1	Induction
miR-503	Decreased	Cyclin D1, Cyclin E2, CDC25A, CDKN1B, CHK1	Suppression
miR-23a	Decreased	TNF-α, c-Myc CCNL2, HNF4G MET	Suppression
miR-150	Decreased	TNF-α, survivin, FoxP1, c-Myb	Suppression
miR-663	Decreased	TGF-β1, AP-1, Jun-B, Jun-D	Suppression
miR-378	Decreased	Odc1	Suppression
miR-34a	Decreased	INHBB	Suppression
miR-33	Decreased	CDK6, EEF1A1, RAP2A	Suppression
miR-26a	Decreased	MAP3K2, MXI1, SENP5, CCND2, CCNE2	Suppression

miRNA: Micro ribonucleic acids; PTEN: Phosphatase and tensin homolog; LR: Liver regeneration; TNF-α: Tumor necrosis factor-α; CDK-6: Cyclin-dependent kinase 6.