Copyright
©The Author(s) 2021.
World J Hepatol. Feb 27, 2021; 13(2): 242-260
Published online Feb 27, 2021. doi: 10.4254/wjh.v13.i2.242
Published online Feb 27, 2021. doi: 10.4254/wjh.v13.i2.242
Variables | Number of studies | Sample sizes | OCI prevalence across studies | Pooled OCI prevalence (%) | Heterogeneity | |||
Range (%) | Median | Mean (%) | 95%CI | Cochran’s Q | I-squared (%) | |||
Countries | ||||||||
Egypt | 5 | 1689 | 3.91-44.44 | 11.33 | 16.08 | 5.81-37.35 | 152.4a | 97.4 |
Iran | 5 | 272 | 0-32.08 | 10.14 | 11.46 | 3.64-30.73 | 16.6b | 76.0 |
Pakistan | 1 | 104 | - | - | 0.48 | 00.03-7.15 | - | - |
Temporal duration1 | ||||||||
Before 2015 | 8 | 523 | 0-44.44 | 10.46 | 11.83 | 4.84-26.14 | 46.0a | 84.8 |
2015 and thereafter | 3 | 1542 | 3.91-34.82 | 11.33 | 12.28 | 3.23-36.99 | 111.1a | 98.2 |
Method of HCV RNA detection | ||||||||
RT-nested PCR | 6 | 359 | 0-44.44 | 21.11 | 21.38 | 11.73-35.75 | 30.5a | 83.6 |
Real time RT-PCR | 4 | 1636 | 0-11.33 | 7.35 | 6.29 | 2.73-13.84 | 23.9a | 87.4 |
RT-PCR | 1 | 70 | - | - | 12.86 | 6.83-22.90 | - | - |
Patients’ subpopulation | ||||||||
Post-HCV non-viremic cases2 | 5 | 1716 | 0-34.82 | 11.33 | 9.14 | 3.02-24.53 | 116.8a | 96.6 |
Cryptogenic liver diseases3 | 4 | 212 | 8.89-44.44 | 21.11 | 20.81 | 6.87-48.35 | 22.6a | 86.7 |
Chronic HCV infection and Cryptogenic liver diseases2,3 | 1 | 102 | - | - | 10.78 | 6.07-18.43 | - | - |
Autoimmune hepatitis | 1 | 35 | - | - | 1.39 | 0.09-18.67 | - | - |
Patients’ HCV serostatus | ||||||||
Seronegative | 5 | 247 | 0-44.44 | 10.14 | 16.13 | 5.41-39.28 | 27.7a | 85.6 |
Seropositive | 5 | 1716 | 0-34.82 | 11.33 | 9.11 | 2.97-24.69 | 116.8a | 96.6 |
Seronegative/seropositive | 1 | 102 | - | - | 10.78 | 6.07-18.43 | - | - |
Sample size | ||||||||
Less than 100 | 6 | 317 | 0-44.44 | 11.50 | 15.63 | 6.08-34.67 | 32.2a | 84.5 |
100 and above | 5 | 1748 | 0-34.82 | 10.78 | 8.88 | 3.04-23.26 | 116.0a | 96.5 |
All studies | 11 | 2065 | 0-44.44 | 10.78 | 12.04 | 5.87-23.10 | 179.3a | 94.4 |
- Citation: Hedayati-Moghaddam MR, Soltanian H, Ahmadi-Ghezeldasht S. Occult hepatitis C virus infection in the Middle East and Eastern Mediterranean countries: A systematic review and meta-analysis. World J Hepatol 2021; 13(2): 242-260
- URL: https://www.wjgnet.com/1948-5182/full/v13/i2/242.htm
- DOI: https://dx.doi.org/10.4254/wjh.v13.i2.242