New stem cell autophagy surrogate diagnostic biomarkers in early-stage hepatocellular carcinoma in Egypt: A pilot study

Figure 1 Bioinformatic search and validation of the newly diagnostic biomarkers. A: miR-519d-3p and SQSTM1 as a targeted mRNA according to miRDB (http://mirdb.org/cgi-bin/search.cgi?searchType=miRNA&full=mirbase&searchBox=MIMAT0002853); B: A network of 923 genes targeted by hsa-miR-519d-3p, along with focusing on SQSTM1 in the network (miRTargetLink Human) (https://ccb-web.cs.uni-saarland.de/mirtargetlink/network.php?type=miRNA&qval=hsa-miR-519d-3p); C: The expression of miR-519d in liver tissue and other tissues (https://www.genecards.org/); D: The tissue expression of SQSTM1 is low in hepatocytes of healthy liver tissue (www.proteinatlas.org); E: The expression of SQSTM1 in cancers and liver cancer specifically (www.proteinatlas.org).