Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study

Table 3 Risk factors for post-Liver Transplant development of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis using univariate and multivariate Cox regression analysis

	NAFLD				NASH
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95%CI)	P value	aHR (95%CI)	P value	HR (95%CI)	P value	aHR (95%CI)	P value
Female sex (yes vs no)	0.6 (0.4-1.2)	0.1	0.9 (0.3-1.7)	0.5	0.6 (0.3-1.1)	0.1	0.9 (0.4-2.1)	0.8
Age (per year)	1.0 (0.9-1.0)	0.6			1.0 (0.9-1.0)	0.9
BMI (per kg/m2)	1.1 (1.0-1.2)	< 0.01	1.1 (1.0-1.2)	< 0.01	1.1 (1.0-1.2)	0.01	1.1 (1.0-1.3)	< 0.01
Diabetes (yes vs no)	1.7 (1.0-2.7)	0.02			1.3 (0.7-2.1)	0.3
Dyslipidemia (yes vs no)	4.6 (1.7-12.8)	< 0.01			4.4 (1.5-13)	0.007
ALT (per U/L)	1.0 (0.9-1.0)	0.09	1 (0.9-1.0)	0.3	1.0 (1.0-1.0)	0.03	1 (0.9-1.0)	0.1

aHR: Adjusted hazard ratio; ALT: Alanine aminotransferase; BMI: Body mass index; CI: Confidence interval; HR: Hazard ratio; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis.