Non-alcoholic steatohepatitis in liver transplant recipients diagnosed by serum cytokeratin 18 and transient elastography: A prospective study

Table 2 Diagnostic accuracy of non-invasive tests compared to liver histology (N = 35 from 24 patients)

	NAFLD		NASH	Liver fibrosis
	CAP	HSI	CAP + CK-18	LSM	FIB-4	APRI
Sensitivity (%)	58	64.3	75	61.9	7.1	14.3
Specificity (%)	86	33	83	54.2	73.9	78.3
PPV (%)	70	39	37	54.2	14.3	28.6
NPV (%)	79	58	96	61.9	56.7	60
LR+	4.28	0.96	4.5	1.35	0.27	0.66
LR-	0.48	1.07	0.3	0.7	1.26	1.1
Accuracy (%)	76	45.7	82	57.8	48.7	54.1

APRI: Aspartate aminotransferase-to-Platelets Ratio Index; CAP: Controlled attenuation parameter; CK-18: Cytokeratin 18; FIB-4: Fibrosis 4 index; HSI: Hepatic steatosis index; LSM: Liver stiffness measurement; LR: Likelihood ratio; MELD-Na: Model for end stage liver disease-sodium; NAFLD: Nonalcoholic fatty liver disease; NASH: Nonalcoholic steatohepatitis; NPV: Negative predictive value; PPV: Positive predictive value.