Use of oral vancomycin in children with autoimmune liver disease: A single centre experience

Table 3 Demographic, biochemical and histological features of 12 patients with autoimmune liver disease treated with oral vancomycin

Patients/ diagnosis	Gender	Age at diagnosis (yr)	Type of presentation	IBD	Splenomegaly1	IgG > ULN	Auto-antibodies	Histology				Medications
								Interface hepatitis	Fibrosis	Cirrhosis	Biliopathy3
AIH	F	4.2	Asymptomatic	IC	Not	Yes	SMA 1:40; p-ANCA	No	Yes	No	Yes	Pred/MMF/UDCA/Mesa
AIH	F	10.9	Asymptomatic	UC	Not	Yes	ANA 1:320; SMA 1:160; p-ANCA positive	Yes	Yes	No	Yes	Pred/UDCA/Mesa
ASC	F	16	Insidious	None	Yes	Not	ANA 1:160; p-ANCA positive	Yes	Yes	Yes	No	Pred/MMF/UDCA
ASC	M	4.3	Asymptomatic	CD	Not	Yes	ANA 1:160; SMA 1:160; p-ANCA +++	Yes	Yes	No	Yes	Pred/UDCA/Mesa
ASC	F	8.6	Insidious	UC	Not	Not	SMA 1:40; p-ANCA positive	No	No	No	Yes	Pred/AZA/UDCA/Mesa
ASC	F	12.1	Insidious	UC2	Not	Not	SMA 1:40; p-ANCA positive	No	No	No	Yes	Pred/AZA/UDCA
ASC	M	14.1	Insidious	None	Not	Not	SMA 1:40; p-ANCA positive	Yes	Yes	No	Yes	Pred/AZA/UDCA
ASC	M	14.3	Acute	UC	Not	Yes	ANA 1:320; SMA 1:320	Yes	No	No	Yes	Pred/UDCA/Mesa
ASC	F	13.8	Asymptomatic	UC	Yes	Yes	ANA 1:640; p-ANCA positive	No	Yes	Yes	Yes	Pred/MMF/UDCA/Mesa
ASC	F	5.1	Acute	IC	Not	Not	ANA 1:160; p-ANCA positive	No	Yes	No	Yes	Pred/MMF/UDCA/Mesa
ASC	F	13.1	Acute	CD	Yes	Yes	ANA 1:80; p-ANCA positive	No	Yes	No	Yes	Pred/MMF/UDCA/Mesa
ASC	F	3.6	Asymptomatic	UC	Yes	Not	ANA 1:160; SMA 1:80; p-ANCA positive	Yes	Yes	No	Yes	Pred/MMF/UDCA/Mesa

¹Spleen size detected on liver scan o magnetic resonance cholangiopancreatography.

²Patient underwent colectomy at age of 14 years.

³It includes at least one of the following: Inflammatory injury of the bile duct, ductular reaction, periductular fibrosis, biliary metaplasia, granulomatous cholangitis[16].

AIH: Autoimmune hepatitis; ASC: Autoimmune sclerosing cholangitis; IBD: Inflammatory bowel disease; UC: Ulcerative colitis, CD: Crohn disease; IC: Indeterminate colitis; ULN: Upper limit of normal; F: Female; M: Male; ANA: Anti-nuclear antibody; SMA: Smooth muscle antibody; ANCA: Anti-neutrophil cytoplasmic antibodies; Pred: Prednisone; UDCA: Ursodeoxycholic acid; MMF: Mycophenolate mofetil; Mesa: Mesalazyne.