Retrospective Study
Copyright ©The Author(s) 2021.
World J Hepatol. Dec 27, 2021; 13(12): 2113-2127
Published online Dec 27, 2021. doi: 10.4254/wjh.v13.i12.2113
Table 1 Laboratory and histological features at diagnosis of 75 children with autoimmune liver disease
All patients, n = 75
AIH, n = 54
ASC, n = 21
P value
Biochemical profile
AST U/L (NV ≤ 45)438 (129-982)678 (204-1200)150 (94-333)< 0.001
GGT U/L (NV ≤ 50)116 (60-296)107 (54-196)360 (68-607)< 0.001
Total bilirubin (NV ≤ 1 mg/dL)1.7 (0.6-4.5)2.7 (0.6-5.3)1.2 (0.7-2.5)0.05
ALP (NV ≤ 350 U/L)296 (204-469)283 (199-462)301 (242-494)0.328
ALP/AST ratio0.7 (0.3-2.2)0.4 (0.2-1.6)2.3 (0.7-3.5)0.002
Albumin (NV: 30-50 g/dL)42 (38-44)42 (37-44)42 (40-46)0.082
INR (NV: 0.9-1.2)1.2 (1.1-1.5)1.2 (1.1-1.6)1.1 (1.0-1.2)< 0.05
Platelet (109/L)252 (180-350)234 (167-314)319 (251-393)< 0.05
Autoimmune profile
ANA (≥ 1:20): n (%)55 (73)38 (70)17 (81)0.777
SMA (≥ 1:20): n (%)53 (71)38 (70)15 (71)1
Anti-LKM-1 (≥ 1:10): n (%)12 (16)12 (22)0 (0)< 0.05
Anti-LC1: n (%)9 (12)9 (17)0 (0)< 0.05
ANCA: n (%)37 (49)22 (41)15 (71)< 0.05
IgG g/dL (NV: 0.5-1.8 g/dL)2.0 (1.4-3.2)2.3 (1.4-3.3)1.7 (1.5-2.2)0.325
IgG > ULN: n (%)51 (68)37 (69)14 (67)1
Histology, n (%)
Interface hepatitis51 (68)42 (78)12 (57)0.09
Fibrosis61 (81)42 (78)19 (90)0.324
Cirrhosis17 (23)15 (28)2 (10)0.127
Features of biliopathy162 (83)37 (68)17 (81)0.764
1It includes at least one of the following: inflammatory injury of the bile duct, ductular reaction, periductular fibrosis, biliary metaplasia, granulomatous cholangitis[16]. Values are expressed as median and interquartile ranges.
AIH: Autoimmune hepatitis; ASC: Autoimmune sclerosing cholangitis; AST: Aspartate aminotransferase; GGT: Gamma-glutamyl transferase; ALP: Alkaline phosphatase; INR: International normalized ratio; ANA: Antinuclear antibody; SMA: Smooth muscle antibody; LKM-1: Liver-kidney microsome antibody type 1; LC1: Liver cytosol antibody type 1; SLA: Liver soluble antigen; ANCA: Anti-neutrophil cytoplasmic LT antibodies; ULN: Upper limit of normal; NV: Normal value.