Biliary complications in recipients of living donor liver transplantation: A single-centre study

Table 8 Relation between biliary complications and graft failure

Variable		No graft failure (n = 149), n (%)	Graft failure (n = 20), n (%)	OR	CI		P value1
					95% LCL	95% UCL
Biliary leakage	-	105 (92.1)	9 (7.9)	2.9	1.1	7.5	0.022
	+	44 (80)	11 (20)
Insertion of pigtail catheter	-	144 (90)	16 (10)	7.2	1.8	29.6	0.0122
	+	5 (55.6)	4 (44.4)
Biliary infection	-	68 (94.4)	4 (5.6)	3.4	1.1	10.5	0.029
	+	81 (83.5)	16 (16.5)
Frequency of biliary infection	Nil	68 (94.4)	4 (5.6)				0.0213
	1-2 Episodes	71 (84.5)	13 (15.5)
	≥ 3 Episodes	10 (76.9)	3 (23.1)
Early biliary infection	-	73 (93.6)	5 (6.4)	2.9	1.0	8.3	0.043
	+	76 (83.5)	15 (16.5)
Biliary stricture	-	98 (89.9)	11 (10.1)	1.6	0.6	4.0	0.345
	+	51 (85)	9 (15)
Frequency of biliary stricture	Nil	98 (89.9)	11 (10.1)				0.1683
	1-2 Episodes	38 (88.4)	5 (11.6)
	≥ 3 Episodes	13 (76.5)	4 (23.5)
Early biliary stricture	-	137 (89)	17 (11)	2.0	0.5	7.9	0.3922
	+	12 (80)	3 (20.0)
Need for ERCP	-	98 (89.9)	11 (10.1)	1.6	0.6	4.0	0.345
	+	51 (85)	9 (15.0)
Frequency of ERCP	Nil	98 (89.9)	11 (10.1)				0.1883
	1-2 ERCP	37 (88.1)	5 (11.9)
	≥ 3 ERCP	14 (77.8)	4 (22.2)
Number of stents introduced for stricture	Nil	101 (90.2)	11 (9.8)				0.1363
	1-2 Stents	30 (88.2)	4 (11.8)
	≥ 3 Stents	18 (78.3)	5 (21.7)
Need for PTC	-	142 (88.2)	19 (11.8)	1.1	0.1	9.2	1.0002
	+	7 (87.5)	1 (12.5)
Frequency of PTC	Nil	142 (88.2)	19 (11.8)				0.3743
	1 PTC	7 (100)	0 (0)
	2 PTC	0 (0)	1 (100)
Surgical intervention for stricture	-	148 (88.1)	20 (11.9)	0.9	0.8	0.9	1.0002
	+	1 (100)	0 (0)
HCV PCR at occurrence of stricture	Negative	13 (86.7)	2 (13.3)				0.2923
	Below 200000 IU	13 (86.7)	2 (13.3)
	200000 to 2 million	18 (94.7)	1 (5.3)
	More than 2 million	7 (63.6)	4 (36.4)
Antiviral treatment in relation to stricture	Not given	24 (88.9)	3 (11.1)				0.8362
	Before stricture	11 (78.6)	3 (21.4)
	After stricture	5 (83.3)	1 (16.7)
	During occurrence of stricture	11 (84.6)	2 (15.4)
Admission related to BC	-	85 (89.5)	10 (10.5)	1.3	0.5	3.4	0.551
	+	64 (86.5)	10 (13.5)
Frequency of admissions related to BC	Nil	85 (89.5)	10 (10.5)				0.119
	1-2 ERCP	38 (95)	2 (5)
	≥3 ERCP	26 (76.5)	8 (23.5)
Recurrent HCV infection	-	118 (92.2)	10 (7.8)	3.8	1.5	10.0	0.0102
	+	31 (75.6)	10 (24.4)
Resolution of recurrent HCV	-	0 (0)	4 (100)	6.2	3.0	12.8	0.0022
	+	31 (83.8)	6 (16.2)

¹Pearson chi-squared test unless otherwise indicated.

²Fisher’s exact test.

³Chi-squared test for trend.

Data are presented as number (n) and percentage (%). OR: Odds ratio; LCL: Lower confidence limit; UCL: Lower confidence limit; ERCP: Endoscopic retrograde cholangiopancreatography; PTC: Percutaneous transhepatic cholangiography; PCR: Polymerase chain reaction; HCV: Hepatitis C virus; BC: Biliary complication.