Biliary complications in recipients of living donor liver transplantation: A single-centre study

Table 6 Relation between biliary complications and chronic graft rejection

Variable		No Chronic graft rejection (n = 142), n (%)	Chronic graft rejection (n = 27), n (%)	OR	CI		P value1
					95% LCL	95% UCL
Biliary leakage	-	100 (87.7)	14 (12.3)	2.2	1.0	5.1	0.059
	+	42 (76.4)	13 (23.6)
Insertion of pigtail catheter for biliary leakage	-	135 (84.4)	25 (15.6)	1.5	0.3	7.9	0.6372
	+	7 (77.8)	2 (22.2)
Biliary infection	-	68 (94.4)	4 (5.6)	5.3	1.7	16.1	0.001
	+	74 (76.3)	23 (23.7)
Frequency of biliary infection	Nil	68 (94.4)	4 (5.6)				< 0.0013
	1-2 Episodes	68 (81)	16 (19)
	≥ 3 Episodes	6 (46.2)	7 (53.8)
Early biliary infection	-	73 (93.6)	5 (6.4)	4.7	1.7	13.0	0.002
	+	69 (75.8)	22 (24.2)
Biliary stricture	-	99 (90.8)	10 (9.2)	3.9	1.7	9.2	0.001
	+	43 (71.7)	17 (28.3)
Frequency of biliary strictures	Nil	99 (90.8)	10 (9.2)				0.0013
	1-2 Episodes	32 (74.4)	11 (25.6)
	≥ 3 Episodes	11 (64.7)	6 (35.3)
Early biliary stricture	-	134 (87)	20 (13)	5.9	1.9	17.9	0.0032
	+	8 (53.3)	7 (46.7)
Need for ERCP	-	99 (90.8)	10 (9.2)	3.9	1.7	9.2	0.001
	+	43 (71.7)	17 (28.3)
Frequency of ERCP	Nil	99 (90.8)	10 (9.2)				0.0013
	1-2 ERCP	31 (73.8)	11 (26.2)
	≥ 3 ERCP	12 (66.7)	6 (33.3)
Number of stents introduced for stricture	Nil	102 (91.1)	10 (8.9)				0.0023
	1-2 stents	25 (73.5)	9 (26.5)
	≥ 3 stents	15 (65.2)	8 (34.8)
Need for PTC	-	136 (84.5)	25 (15.5)	1.8	0.3	9.5	0.6152
	+	6 (75)	2 (25)
Frequency of PTC	Nil	136 (84.5)	25 (15.5)				0.1903
	1 PTC	6 (85.7)	1 (14.3)
	2 PTC	0 (0)	1 (100)
Surgical intervention for stricture	-	141 (83.9)	27 (16.1)	0.8	0.8	0.9	1.0002
	+	1 (100)	0 (0)
HCV PCR at occurrence of stricture	Negative	10 (66.7)	5 (33.3)				0.6603
	Below 200000 IU	12 (80)	3 (20)
	200000 to 2 million	15 (78.9)	4 (21.1)
	More than 2 million	6 (54.5)	5 (45.5)
Antiviral treatment in relation to stricture	Not given	21 (77.8)	6 (22.2)				0.5362
	Before stricture	9 (64.3)	5 (35.7)
	After stricture	4 (66.7)	2 (33.3)
	During occurrence of stricture	9 (69.2)	4 (30.8)
Admission related to BC	-	85 (89.5)	10 (10.5)	2.5	1.1	5.9	0.028
	+	57 (77)	17 (23)
Frequency of admissions related to biliary complications	Nil	85 (89.5)	10 (10.5)				0.0023
	1-2	35 (87.5)	5 (12.5)
	≥ 3	22 (64.7)	12 (35.3)
Recurrent HCV	-	116 (90.6)	12 (9.4)	5.6	2.3	13.3	< 0.001
	+	26 (63.4)	15 (36.6)
Resolution of recurrent HCV	-	1 (25)	3 (75)	0.2	0.0	1.7	0.1302
	+	25 (67.6)	12 (32.4)

¹Pearson chi-squared test unless otherwise indicated.

²Fisher’s exact test.

³Chi-squared test for trend.

Data are presented as number (n) and percentage (%). OR: Odds ratio; LCL: Lower confidence limit; UCL: Lower confidence limit; ERCP: Endoscopic retrograde cholangiopancreatography; PTC: Percutaneous transhepatic cholangiography; PCR: Polymerase chain reaction; HCV: Hepatitis C virus; BC: Biliary complication.