De novo and recurrence of metabolic dysfunction-associated fatty liver disease after liver transplantation

Table 2 Summary of clinical significances and outcomes of de novo and recurrent metabolic dysfunction-associated fatty liver disease in post liver transplant patients

	De novo MAFLD	Recurrent MAFLD
Risk factors/Predictors for post LT MAFLD	Post LT weight gain	Post LT weight gain
	HCV	Post-transplant hypertriglyceridemia
	Sirolimus-based immunosuppressant therapy	Steroid
	Insulin resistance/diabetes mellitus	Post LT Metabolic syndrome
		Insulin use
		Insulin resistance/ diabetes mellitus
Progression to steatohepatitis and advanced fibrosis	Less common	More common
Cardiovascular events	Common	Common
Patient and graft survival	No significant impact	No significant impact

LT: Liver transplant; HCV: Hepatitis C virus; MAFLD: Metabolic dysfunction-associated fatty liver disease.