Genotype E: The neglected genotype of hepatitis B virus

Table 1 Recombination events of genotype E with breakpoints across the genome

Parental genotype	Region	Genome position (from the EcoRI site)	Country
D/E	preS1		Niger, Ghana, Gabon, and Sudan[53-58]
D/E	preC/C		Ireland[59] and South Africa[60]
D/E	Pol	978, 1230	Sudan[56]
	X	1643
	C/Pol overlapping region	2384
	Pol	2756
	preS1/Pol overlapping region	3000
D/E	X/preC overlapping region	1649, 1932	Niger[58]
	C/Pol overlapping region	2392, 2385
	Pol	2831, 2836
	Pol/preS1 overlapping region	3075, 3083
D/E	X	1651	Ghana[57]
	C/Pol overlapping region	2406
	Pol	2823
	Pol/preS1 overlapping region	3081
E/D	preS	85-505	Niger[58]
	S-Pol overlapping region	796-1306
A/E	C		Ghana[57]
A/E	Pol	874-1062	Cameroon[37]
	X
E/A	Pol	908-1026
	X-C
A/E	preC/C		Guinea[57] and France[61]
E/A	X

The precore/core (preC/C) encodes the e antigen (HBeAg) and core protein (HBcAg); Pol for polymerase (reverse transcriptase), preS1 encodes the large surface protein and X is a transcriptional transactivator protein.