Role of immune dysfunction in drug induced liver injury

Figure 4 Mechanism of autoimmune drug-induced liver injury. A: Drug causes mitochondrial dysfunction resulting in cell death and release of HMGB-1 and other stress signals; B: Kupffer cells and Stellate cells get activated. Release cytokines, chemokines and toxins; C: Chemokines attract monocytes; D: Amplification of injury and cell death. KC: Kupffer cell; HSC: Hepatic stellate cells; ROS: Reactive oxygen species.