Role of immune dysfunction in drug induced liver injury

Figure 3 Immune allergic drug-induced liver injury. A: Endoplasmic reticulum stress by drug, causes misfolded protein resulting in cell death and release of stress signals and drug-protein complex. Kupffer cells ingest the drug-protein complex to T-helper cells; B: T-helper cells process it and present it to B-cells; C: B-cells produce anti-drug antibodies; D: These antibodies target the tissues, where drug is accumulated. KC: Kupffer cell; HSC: Hepatic stellate cells.