Chelation therapy in liver diseases of childhood: Current status and response

Figure 2 Pathogenesis of gestational alloimmune liver disease. Alloimmunization of fetal liver antigen by maternal blood produces IgG antibody passively transferred through the placenta to cause fetal liver injury by complement activation. Liver injury reduces the hepatic synthesis of hepcidin resulting in uncontrolled placental iron absorption. Excess iron is deposited in liver, pancreas, heart, gonads, etc.