Nonalcoholic fatty liver disease is associated with worse intestinal complications in patients hospitalized for Clostridioides difficile infection

Table 1 Comparison of demographic data for patients hospitalized with Clostridioides difficile infection with coexisting nonalcoholic fatty liver disease, viral liver disease and alcoholic liver disease

Variables	CDI with NAFLD	CDI with VLD	CDI with ALD	P value
n (weighted)	7239	11857	5938	CDI with NAFLD vs CDI with VLD	CDI with NAFLD vs CDI with ALD
Age (yr)	56.32 ± 0.42	57 ± 0.26	56.13 ± 0.37	0.15	0.73
18-39	1133 (15.6%)	791 (6.7%)	557 (9.4%)	< 0.0001	< 0.0001
40-49	1290 (17.8%)	1811 (15.3%)	1051 (17.7%)
50-59	1618 (22.4%)	4873 (41.1%)	2021 (34%)
60-69	1620 (22.4%)	2791 (23.5%)	1439 (24.2%)
≥ 70	1578 (21.8%)	1591 (13.4%)	870 (14.7%)
Sex				< 0.0001	< 0.0001
Female	5023 (69.4%)	5795 (48.9%)	2300 (38.7%)
Race				< 0.0001	0.17
Caucasian	5427 (75%)	6920 (58.4%)	4358 (73.4%)
African American	482 (6.5%)	2773 (23.4%)	525 (8.8%)
Hispanic	648 (9%)	1144 (9.6%)	515 (8.7%)
Hospital bed size				0.033	0.9
Large	4241 (58.6%)	7414 (62.6%)	3461 (58.3%)
Hospital region				< 0.0001	< 0.0001
Northeast	1091 (15.1%)	2618 (22.1%)	1243 (20.9%)
Midwest	1618 (22.3%)	2514 (21.1%)	1584 (26.7%)
South	3008 (41.6%)	4208 (35.5%)	1671 (28.1%)
West	1522 (21%)	2517 (21.2%)	1440 (24.3%)
Hospital type				< 0.0001	0.22
Urban teaching	3401 (47%)	7207 (60.8%)	3065 (51.6%)
Insurance				< 0.0001	< 0.0001
Medicare	3086 (42.6%)	5493 (46.3%)	2239 (37.7%)
Medicaid	914 (12.6%)	3329 (28.1%)	1261 (21.2%)
Private	2526 (34.9%)	1835 (15.5%)	1391 (23.4%)
Median household income for ZIP Code, %				< 0.0001	0.61
Q1	1790 (24.7%)	4205 (35.5%)	1592 (26.8%)
Q2	1824 (25.2%)	3128 (26.4%)	1407 (23.7%)
Q3	1926 (26.6%)	2353 (19.8%)	1503 (25.3%)
Q4	1511 (20.9%)	1657 (14%)	1252 (21.1%)

Values reported as weighted mean ± SE and weighted number [n (%)]. CDI: Clostridioides difficile infection; NAFLD: Nonalcoholic fatty liver disease; VLD: Viral liver disease; ALD: Alcoholic liver disease; Q1: Quartile 1, 0-25th percentile; Q2: Quartile 2, 26th-50th percentile; Q3: Quartile 3, 51th-75th percentile; Q4: Quartile 4, 76th-100th percentile.