Do peripartum and postmenopausal women with primary liver cancer have a worse prognosis? A nationwide cohort in Taiwan

Table 2 Cox model measured hazard ratios and 95% confidence intervals of death associated non-peripartum primary liver cancer and peripartum primary liver cancer patients

Characteristics	Event, n = 124	Person, yr	IR	Crude		Adjusted
				HR (95%CI)	P value	HR (95%CI)	P value
Peripartum primary liver cancer
No	97	587	16.53	Ref.		Ref.
Yes	27	99	27.17	1.35 (0.88-2.08)	0.166	1.40 (0.89-2.20)	0.149
Age at baseline
< 30	54	350	15.44	Ref.		Ref.
30-34	39	169	23.08	1.21 (0.80-1.84)	0.359	1.47 (0.95-2.28)	0.083
35-49	31	167	18.52	1.29 (0.83-2.00)	0.266	1.13 (0.69-1.85)	0.617
Baseline comorbidity
HBV	27	230	11.72	0.52 (0.34-0.80)	0.003	0.48 (0.30-0.77)	0.002
Unspecified chronic hepatitis	1	11	9.04	0.86 (0.12-6.17)	0.882	0.56 (0.08-4.10)	0.565
Alcoholic liver disease	6	8	73.37	2.85 (1.25-6.49)	0.013	2.15 (0.73-6.36)	0.165
Cirrhosis	7	40	17.55	1.12 (0.52-2.40)	0.773	1.49 (0.57-3.90)	0.411
Biliary stone	4	11	35.47	1.23 (0.45-3.33)	0.686	0.64 (0.17-2.35)	0.499
Cholecystitis	5	80	6.26	0.43 (0.18-1.06)	0.066	0.30 (0.12-0.75)	0.010
Cholangitis	7	4	179.30	3.76 (1.71-8.26)	< 0.001	3.34 (1.49-7.47)	0.003

Adjusted HR: Adjusted for gender, age, and all comorbidities in Cox proportional hazards regression; CI: Confidence interval; HR: Hazard ratios; HBV: Hepatitis B virus; IR: Incidence rate.