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Copyright ©The Author(s) 2021.
World J Hepatol. Nov 27, 2021; 13(11): 1642-1652
Published online Nov 27, 2021. doi: 10.4254/wjh.v13.i11.1642
Table 1 Overview of the studies assessing aspects of health-related quality of life in autoimmune hepatitis
Ref.
Country
Population (n)
Biochemical remission (%)
Cirrhosis (%)
Questionnaire
Factors/results
van der Plas et al[13], 2007The NetherlandsAIH (142), other liver diseases (776)--SF-36, MFI-20, LDSIHRQoL impairment; Association with: Fatigue
Afendy et al[8], 2009United States, ItalyAIH (13), other chronic liver diseases (1090)-84.61SF-36HRQoL impairment; Negative correlation: Age (every scale), female gender (primary predictor of mental health), cirrhosis (every scale, primary predictor of physical health)
Schramm et al[12], 2014GermanyAIH (103)7727SF-12, PHQ-9, GAD-7HRQoL impairment (total mental score/mental well-being); Association with: depression and anxiety (positive correlation with female gender, corticosteroid use, and concerns about progression of the liver disease)
Takahashi et al[11], 2018JapanAIH (265), chronic hepatitis C (88)-10.6CLDQ, SF-36HRQoL impairment; Negative correlation: Age, cirrhosis, comorbid diseases, corticosteroid use (worry domain), disease duration, AST; Positive correlation: platelet count
Wong et al[14], 2018United KingdomAIH (990)5633EQ-5D-5L, FIS, CFQ, HADSHRQoL impairment; Positive correlation: Biochemical remission; Negative correlation: overlap syndromes, corticosteroid use, and calcineurin inhibitor use
Janik et al[15], 2019PolandAIH (140)-55SF-36, MFIS, PHQ-9, STAIHRQoL impairment (every scale, except role emotional2); Negative correlation: Female gender, depression, trend toward better HRQoL (physical health) with budesonide vs prednisone; Association with: Anxiety, depression, and fatigue
Dirks et al[9], 2019GermanyAIH (27), AIH/PBC (8), other liver diseases (97)-0SF-36, FIS, HADSHRQoL impairment; Association with: Anxiety, depression, and fatigue
Castellanos-Fernández et al[7], 2021CubaAIH (22), overlap syndrome of AIH and PBC (7), PBC (14), other liver diseases (500)-43.93FACIT-F, WPAI:SHP, CLDQHRQoL impairment; Positive correlation: Male gender, exercising > 90 min/wk; Negative correlation: Fatigue, abdominal pain, anxiety, depression, and extrahepatic comorbidity (diabetes mellitus type 2, sleep apnea)
Cortesi et al[10], 2020ItalyAIH (51), other chronic liver diseases (2911)-0EQ-5D-3LHRQoL impairment in AIH