Liver involvement in inflammatory bowel disease: What should the clinician know?

Table 2 Main features of drug-induced liver injury in inflammatory bowel disease

Drug	Characteristics of drug induced liver injury
Aminosalicylates	Increases in LFT; Cholestatic pattern; Rarely eosinophilia
Thiopurines	Influenced by TMPT polymorphisms > increase in 6-MMP, the hepatotoxic molecule; Increases in LFT; Idiosyncratic cholestatic reaction; Fever, rash, lymphadenopathy and hepatomegaly; Nodular regenerative hyperplasia
Anti-TNF	Idiosyncratic reaction > dose-dependent mechanism; Hepatocellular injury > cholestasis; Autoimmune phenomena
Anti-integrins	Rare; Asymptomatic LFT increase
Anti IL12/23	Mild LFT increase

LFT: Liver function test; TMPT: Thiopurine S-methyltransferase; TNF: Tumor necrosis factor.