Focal nodular hyperplasia associated with a giant hepatocellular adenoma: A case report and review of literature

Table 1 Summary of current literature review

No.	Ref.	Sex, age	OC	Pathology - Size (cm)	Location (segment)	Symptoms	Treatment
#1	Dimitroulis et al[26], 2012	F, 18 yr	No	FNH – 2.5	S3	RUQ pain	Wedge resection
				HA – 6	S5-6		Lt S5-6
#2	Di Carlo et al[27], 2003	F, 25 yr	No	FNH – < 5	S4	RUQ pain	En bloc (+ gallbladder)
				HA – NA	S4		Enucleation
				HH – > 4	S2		Enucleation
				HCy – NA	S5		En bloc (+ gallbladder)
#3	Shih et al[28], 2015	F, 40 yr	Yes	FNH – 6	III	Abdominal pain	LH
				HA – 9.5 & small ones (max 1.5 cm)	III for the largest, small ones on both lobes
#4	Laurent et al[29], 2003	F, 45 yr	Yes	FNH – 1	S3	Fatigue	Lt S3 segmentectomy + wedge
				HA – NA	S7		Lt RH
		F, 40 yr	Yes	FNH – 5	S6	None	Biopsy
				FNH – 4	S7		Biopsy
				NA – 3	Left lobe		Lt LH
				HA – 3	Left lobe		Lt LH
		F, 38 yr	Yes	HA surrounded by FNH –13	Right lobe	None	Lt RH
		F, 29 yr	Yes	HA – 5 × 1	S1 (bleeding), S2, 3, 7, 8	Abdominal pain + shock	Lt LH + S1
				FNH – 1	S6
		F, 41 yr	Yes	HA – 1	RL	Abdominal pain	Lt RH
				FNH – 1	RL
#5	Our case-report	F, 38 yr	Yes	6 × 614 × 12 × 6	S3	None	Ls LL

FNH: Focal nodular hyperplasia; HA: Hepatic adenoma; HCy: Hepatic hydatid cyst; HH: Hepatic hemangioma; RL: Right lobectomy; LH: Left hepatectomy; LH: Left hepatectomy; LL Left lobectomy; RUQ: Right upper quadrant; Lt: Laparotomy; Ls: Laparoscopic; F: Female; OC: Oral contraception.