Clinical outcomes of patients with two small hepatocellular carcinomas

doi:10.4254/wjh.v13.i10.1439

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Oct 27, 2021 (publication date) through Feb 11, 2025

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World Journal of Hepatology

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1948-5182

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Hepatol. Oct 27, 2021; 13(10): 1439-1449
Published online Oct 27, 2021. doi: 10.4254/wjh.v13.i10.1439

Table 1 Baseline characteristics of 104 patients with two hepatocellular carcinomas according to synchronous or sequential tumor

	All (n = 104)	Synchronous group (n = 59)	Sequential group (n = 45)	P value
Age, yr, median (IQR)	63 (10)	63 (10)	63 (9)	0.41
Gender, n (%)				0.08
Male	89 (85.6)	51 (86.4)	38 (84.4)
Female	15 (14.4)	8 (13.6)	7 (15.6)
Aetiology, n (%)				0.73
Alcohol	12 (11.5)	8 (13.6)	4 (8.9)
HCV	42 (40.4)	22 (37.3)	20 (44.4)
HBV	15 (14.4)	8 (13.6)	7 (15.6)
NASH	5 (4.8)	4 (6.8)	1 (2.2)
Alcohol and HCV	18 (17.3)	9 (15.3)	9 (20.0)
Other¹	12 (11.5)	8 (13.6)	4 (8.9)
Cirrhosis status, n (%)				0.07
Non-cirrhotic	10 (9.6)	3 (5.1)	7 (15.6)
Cirrhotic	94 (90.4)	56 (94.9)	38 (84.4)
CTP class, n (%)				0.1
A	66 (63.5)	35 (59.3)	31 (68.9)
B	25 (24.0)	13 (22.0)	12 (26.7)
C	13 (12.5)	11 (18.6)	2 (4.4)
MELD, median (IQR)	9.6 (6)	11 (7)	8 (5)	0.01
AFP (μg/L), median (IQR)	9.6 (24.0)	8.6 (26.0)	10.4 (22.8)	0.61
Combined tumour diameter (cm), median (IQR)	3.5 (1.7)	3.8 (1.7)	3.4 (1.2)	0.28
Transplanted, n (%)	25 (24)	18 (30.5)	7 (15.6)	0.08
Death, n (%)	36 (34.6)	23 (39.0)	13 (28.9)	0.28

¹Other refers to aetiologies not listed here and is inclusive of: Mixed aetiologies, autoimmune hepatitis, hereditary haemochromatosis, α-1-antitrypsin deficiency and cryptogenic liver disease. IQR: Interquartile range; AFP: α-feto protein; CTP: Child-Turcotte-Pugh; HBV: Hepatitis B virus; HCV: Hepatitis C virus; MELD: Model for End-Stage Liver Disease score; NASH: Non-alcoholic steatohepatitis.

Citation: Pham AD, Vaz K, Ardalan ZS, Sinclair M, Apostolov R, Gardner S, Majeed A, Mishra G, Kam NM, Patwala K, Kutaiba N, Arachchi N, Bell S, Dev AT, Lubel JS, Nicoll AJ, Sood S, Kemp W, Roberts SK, Fink M, Testro AG, Angus PW, Gow PJ. Clinical outcomes of patients with two small hepatocellular carcinomas. World J Hepatol 2021; 13(10): 1439-1449
URL: https://www.wjgnet.com/1948-5182/full/v13/i10/1439.htm
DOI: https://dx.doi.org/10.4254/wjh.v13.i10.1439